NCT01805479

Exercise Training in Depressed Traumatic Brain Injury Survivors

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Virginia Commonwealth University · Academic / Other
• Sex: All
• Age: 14 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the feasibility of successfully delivering moderate intensity aerobic exercise training to depressed traumatic brain injury subjects between one and three years after injury.

Detailed description

Traumatic brain injury (TBI) alters the lives of many civilians and those involved in armed conflicts. Sequelae of TBI includes depression in up to 30% of cases. Appearance of depression after TBI impairs recovery and results in sub-optimal re-integration into society. Treatment of post TBI depression relies on oral medications, whose efficacy and side effect profile is sub-optimal. Exercise training is effective in spontaneous depression as a stand alone treatment and in conjunction with oral medications, and this may represent an alternative treatment option in the TBI population. Further, the pathophysiology of depression after TBI has yet to be examined with the full scientific rigor required. This project proposes to use exercise training of moderate intensity as a treatment for depression after TBI, while measuring biological markers as a way to investigate efficacy and provide insight into the pathophysiology.

Conditions

• Depression
• Traumatic Brain Injury

Interventions

Type	Name	Description
OTHER	aerobic exercise	the active arm will be asked to perform 60% of maximum heart rate
OTHER	stretching and flexibility program	stretching and flexibility program for the Placebo Comparator Arm

Timeline

• Start date: 2013-02-01
• Primary completion: 2014-06-01
• Completion: 2014-06-01
• First posted: 2013-03-06
• Last updated: 2015-12-21

Locations

1 site across 1 country: United States