NCT01750723

Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Basic Research on Acetazolamide´s Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.

Detailed description

To investigate headache score and accompanying symptoms during and after infusion of acetazolamide. With magnetic resonance imaging the investigators will investigate changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), diameter of MCA, the Internal carotic artery (ICA), the superficial temporal artery (STA) and the Medial Meningeal artery (MMA).

Conditions

• Headache
• Migraine

Interventions

Type	Name	Description
DRUG	Acetazolamide	1 g diluted in 10 ml saline, i.v. bolus injection.

Timeline

• Start date: 2012-12-01
• Primary completion: 2013-04-01
• Completion: 2013-04-01
• First posted: 2012-12-17
• Last updated: 2013-07-09

Locations

2 sites across 1 country: Denmark