NCT01737255

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome

Magnetic Resonance Imaging Screening In Li Fraumeni Syndrome: An Exploratory Whole Body MRI Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 88 (actual)
• Sponsor: Institute of Cancer Research, United Kingdom · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

This study is aimed at exploring the use of whole body MRI for early cancer detection in TP53 mutation carriers and population controls, with the hypothesis that more cancers will be detected in the TP53 mutation carrier group. A secondary end-point will be the number of incidental findings detected and subsequent investigations required. A series of questionnaires will be used to assess the psychological impact of screening on both the study and control group.

Conditions

• Li-Fraumeni Syndrome

Interventions

Type	Name	Description
OTHER	Whole body MRI	Individuals will undergo whole body and brain MRI
OTHER	Psychological questionnaires	All recruits will complete questionnaires at 6 time points to assess psychological impact

Timeline

• Start date: 2012-10-01
• Primary completion: 2016-09-01
• Completion: 2017-12-01
• First posted: 2012-11-29
• Last updated: 2022-03-31

Locations

1 site across 1 country: United Kingdom