NCT01653223

Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

A Study of Simvastatin on Myocardial Protection and Cardiac Function Undergoing Cardiac Surgery With Cardiopulmonary Bypass

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 369 (estimated)
• Sponsor: Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.

Conditions

• Congenital Heart Disease
• Heart Valve Disease

Interventions

Type	Name	Description
DRUG	simvastatin	In short statin group: 20 mg per day, start at 5-7 days before surgery and continue for 7 days. In long statin group: 20 mg per day, start at 5-7 days before surgery and continue for 6 months.

Timeline

• Start date: 2013-01-01
• Primary completion: 2024-12-01
• Completion: 2026-12-01
• First posted: 2012-07-30
• Last updated: 2023-04-21

Locations

1 site across 1 country: China