NCT01566968

Novel Endpoints in Cough Challenge Testing

Novel Endpoints in Cough Challenge Testing.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 98 (actual)
• Sponsor: Manchester University NHS Foundation Trust · Other Government
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep breath in, or by asking them to just continue to take a number of breaths. The purpose of this clinical research study is to see if the coughing responses are different in healthy people and people with respiratory problems that make them cough when they are given these chemicals in these two methods.

Conditions

• Chronic Obstructive Pulmonary Disease
• Asthma
• Healthy
• Chronic Cough
• Smokers

Interventions

Type	Name	Description
OTHER	Cough challenge test	Cough challenge will be performed with Capsaicin, citric acid and prostaglandin E2.
OTHER	24 hour ambulatory cough recording	Cough recording by using an ambulatory sound recording device.
OTHER	Cough quality of life questionnaire	questionnaire designed to assess impact of cough on a person's life

Timeline

• Start date: 2011-01-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2012-03-30
• Last updated: 2012-04-06

Locations

1 site across 1 country: United Kingdom