NCT01412645

Long-term Investigation of Resveratrol in Obesity

Long-term Investigation of Resveratrol on Management of Metabolic Syndrome, Osteoporosis and Inflammation, and Identification of Plant Derived Anti-inflammatory Compounds

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: Male
• Age: 30 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to investigate potential metabolic effects of resveratrol in men with metabolic syndrome(otherwise healthy). The investigators hypothesize that resveratrol has an anti-inflammatory effect, and will increase insulin sensitivity, change the fat- and sugar-metabolism, and down-regulate bone-turnover.

Detailed description

The study will be done in a collaboration between two PhD students, who focus on effects in adipose- and muscle- tissue, and bone tissue respectively. The investigators will look at changes in * inflammation-markers * biochemical markers of fat- and sugar-metabolism * gene-expression in fat- and muscle-tissue * body composition (DXA (whole body) and MR spectroscopy) * biochemical markers of bone-metabolism * Bone Mineral Density (DXA scans) * bone structure (QCT) * gene-expression and cytokines in bone marrow Some of the volunteers will have their insulin sensitivity measured.

Conditions

• Obesity
• Inflammation
• Insulin Sensitivity
• Osteoporosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Resveratrol	500mg resveratrol 2 times daily for 4 months (High-dose Resveratrol), 75mg resveratrol 2 times daily for 4 months (Low-dose Resveratrol) or 1 placebo 2 times daily for 4 months

Timeline

• Start date: 2011-08-01
• Primary completion: 2013-08-01
• Completion: 2013-08-01
• First posted: 2011-08-09
• Last updated: 2013-12-13

Locations

1 site across 1 country: Denmark