NCT01326208

Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury

Influence of Different Strategies to Optimize Positive End-expiratory Pressure on Pulmonary Gas Exchange, Perfusion/Ventilation Matching and Homogeneity of Ventilation in Patients With Acute Lung Injury

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University Hospital, Bonn · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.

Conditions

• Acute Lung Injury
• Acute Respiratory Distress Syndrome
• Respiratory Failure

Interventions

Type	Name	Description
PROCEDURE	PEEP titration	PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT

Timeline

• Start date: 2011-03-01
• Primary completion: 2012-12-01
• Completion: 2013-06-01
• First posted: 2011-03-30
• Last updated: 2011-03-30

Locations

1 site across 1 country: Germany