NCT01280019

FRC Guided Therapy in Acute Respiratory Failure

Functional Residual Capacity Guided Alveolar Recruitment Strategy in Patients With Acute Respiratory Failure After Cardiac Surgery

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Luebeck · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In ventilated patients with acute respiratory failure endotracheal suctioning may lead to alveolar derecruitment, which can be monitored by means of functional residual capacity (FRC) measurements. Regional distribution of ventilation can be followed at bedside using electrical impedance tomography. The investigators hypothesize that a FRC guided recruitment strategy, aimed at restoring a baseline FRC value after open endotracheal suctioning, improves oxygenation and regional distribution of ventilation. In addition the investigators research the impact of such a strategy on the inflammatory response to mechanical ventilation.

Conditions

• Mechanical Ventilation
• Acute Respiratory Failure
• Cardiac Surgery

Interventions

Type	Name	Description
PROCEDURE	alveolar recruitment manoeuvre	Increase of airway pressures in a stepwise manner from set peak inspiratory pressure/ positive end-expiratory pressure up to 40/15 mbar and back over 2 minutes.

Timeline

• Start date: 2010-10-01
• Primary completion: 2011-12-01
• Completion: 2012-05-01
• First posted: 2011-01-20
• Last updated: 2011-01-20

Locations

1 site across 1 country: Germany