NCT01203501

In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight Infants

In Utero Magnesium Sulfate Exposure: Effects on Extremely-Low-Birth-Weight (ELBW) Infants

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 1,339 (actual)
• Sponsor: NICHD Neonatal Research Network · Network
• Sex: All
• Age: 14 Days
• Healthy volunteers: Accepted

Summary

This study examined the effect of magnesium sulfate (MgSO4) exposure on adverse outcome in extremely low birth weight (ELBW) infants. For infants included in the NICHD Neonatal Research Network Generic Database whose mothers were given prenatal MgSO4, data were prospectively collected on maternal/infant conditions and magnesium exposure (including indications, timing and duration of exposure).

Detailed description

Retrospective studies suggested that the risk of cerebral palsy and intraventricular hemorrhage (IVH) in extremely premature infants of mothers given magnesium sulfate (MgSO4) may be reduced. The purpose of this study was to examine the effects of MgSO4 exposure on adverse outcomes in extremely low birth weight (ELBW) infants. For infants included in the NICHD Neonatal Research Network Generic Database, data were prospectively collected on maternal/infant conditions and MgSO4 exposure (including indications, timing and duration of exposure).

Conditions

• Infant, Newborn
• Infant, Low Birth Weight
• Infant, Small for Gestational Age
• Infant, Premature
• Intracranial Hemorrhages
• Leukomalacia, Periventricular
• Cerebral Palsy

Timeline

• Start date: 1996-07-01
• Primary completion: 1998-06-01
• Completion: 2000-06-01
• First posted: 2010-09-16
• Last updated: 2017-09-26

Locations

15 sites across 1 country: United States