NCT01198964

Optimization of Human Cortical Stimulation

U.S.-German Collaboration: Optimization of Human Cortical Stimulation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 8 (estimated)
• Sponsor: University of Washington · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

We will observe epileptic patients who already have electrodes implanted on the brain and are receiving high-level brain stimulation for clinical purposes while testing their motor and language function. We propose to do a limited, low-level brain stimulation to show that the signatures of local activity in the target area change as an effect of brain stimulation. The goal of this study is to understand the feasibility of a novel recurrent brain-computer interface that could eventually promote targeted functional recovery in subjects who have had a brain injury.

Detailed description

The subject will have already been scheduled for placement of the ECoG electrodes on the surface of the brain and who will, for all clinical purposes, subsequently receive stimulation for mapping of function of the ECoG sites. The decision to place the electrodes on the brain, the location of the electrodes and the length of time the electrodes are in are all part of clinical care. There will be two types of testing, motor and language. Motor will involve inducing stimulation to the thumb cortex and the wrist cortex. There will be a conditioning of this over 4-12 hours. Language will involve showing pictures on a computer screen and the subject will be observed whether speech is disrupted with stimulation or not.

Conditions

• Epilepsy
• Brain Injury

Interventions

Type	Name	Description
PROCEDURE	Low-level cortical stimulation	A couple of electrodes will be stimulated (at a lower level than the stimulation used for standard care) over a period of 4-12 hours based on the signals defined by the motor or language task.

Timeline

• Start date: 2010-09-01
• Primary completion: 2023-08-01
• Completion: 2023-08-01
• First posted: 2010-09-10
• Last updated: 2021-04-27

Locations

1 site across 1 country: United States