NCT01104857

Respiratory Muscle Dysfunction in Critically Ill Patients

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University Medical Center Nijmegen · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available. The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.

Conditions

• Sepsis
• Mechanical Ventilation

Interventions

Type	Name	Description
PROCEDURE	diaphragm muscle biopsy	Biopsy is obtained for biochemical analysis
PROCEDURE	Diaphragm muscle biopsy	Biopsy is obtained for biochemical analysis

Timeline

• Start date: 2010-04-01
• Primary completion: 2016-04-01
• Completion: 2016-04-01
• First posted: 2010-04-16
• Last updated: 2015-06-10

Locations

1 site across 1 country: Netherlands