NCT00994994

Tranexamic Acid in Pediatric Cardiac Surgery

Tranexamic Acid Reduces Blood Loss in Pediatric Cardiac Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 160 (actual)
• Sponsor: Okayama University · Academic / Other
• Sex: All
• Age: 2 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

Tranexamic acid(TXA) is an antifibrinolytic agent to reduce blood loss in cardiac surgery. Previous seven RCTs comparing effects of TXA in pediatric cardiac surgery showed conflict results. The reason why they showed mixed results would be the imbalance of patients population with regard to presence of cyanosis. TXA would reduce blood loss in pediatric cardiac surgery with well balanced patients population.

Conditions

• Blood Loss
• Congenital Heart Disease

Interventions

Type	Name	Description
DRUG	Tranexamic Acid	50 mg/kg of tranexamic acid was given as a bolus at the induction of anesthesia, followed by 15 mg/kg of continuous infusion and another 50 mg/kg into the bypass circuit in TXA group. same volume of normal saline was given in Placebo group.

Timeline

• Start date: 2006-01-01
• Primary completion: 2007-08-01
• Completion: 2008-04-01
• First posted: 2009-10-14
• Last updated: 2009-10-14