NCT00994552

Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure

A Pilot Study: Comparing Physiological Parameters and Outcome Variables Using Pressure Support Ventilation Versus Pressure Controlled Ventilation in Patients With Chronic Respiratory Failure

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Guy's and St Thomas' NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is looking at whether there is a difference in outcomes using two different types of breathing support in those patients who have chronic respiratory failure (patients who under-breathe). There is little data to demonstrate which mode of ventilation is better in terms of physiological outcomes and outcome data relating to patient symptoms. We hypothesize that one type of breathing support: pressure support ventilation would be more comfortable for patients as it more closely matches a patient's own respiratory pattern and and so leads to improved adherence and consequent improvement in quality of life. Patients with respiratory failure will be randomly assigned to receive either pressure support ventilation or pressure control ventilation for the first 6 weeks and then cross-over to receive the mode not previously used for a further 6 weeks. They will have baseline data recorded and then be followed up after each 6 week block.

Conditions

• COPD
• Chest Wall Disease
• Neuromuscular Disease
• Obesity Hypoventilation

Interventions

Type	Name	Description
OTHER	Pressure support ventilation	Pressure support ventilation
OTHER	Pressure control ventilation	Pressure control ventilation

Timeline

• Start date: 2009-08-01
• Primary completion: 2010-04-01
• First posted: 2009-10-14
• Last updated: 2009-10-14

Locations

1 site across 1 country: United Kingdom