NCT00911677

Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Does Apolipoprotein E Genotype Predict Delirium and Postoperative Cognitive Dysfunction?

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Ottawa Hospital Research Institute · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Conditions

• Delirium
• Postoperative Cognitive Dysfunction

Timeline

• Start date: 2005-08-01
• Primary completion: 2008-03-01
• Completion: 2009-05-01
• First posted: 2009-06-02
• Last updated: 2009-06-02

Locations

1 site across 1 country: Canada