NCT00897273

Oral HPV Infection in Young Men

Human Papillomavirus Infection of the Mouth in Young Men and Risk Factors for Oropharyngeal Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 500 (actual)
• Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Academic / Other
• Sex: Male
• Age: 18 Years – 21 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: Gathering information about human papillomavirus infection of the mouth in young men may help doctors learn more about risk factors for oropharyngeal cancer. PURPOSE: This research study is assessing human papillomavirus infection of the mouth in young men and risk factors for oropharyngeal cancer.

Detailed description

OBJECTIVES: * Estimate the prevalence of oral human papillomavirus (HPV) type 16, 18, 6, or 11 infection in young adult men. * Assess the independent effect of distinct sexual practices, including kissing, oral sex, and vaginal intercourse, on oral HPV prevalence. * Estimate the 6-month incidence of HPV infection in this study population. OUTLINE: Participants are assessed for oral human papillomavirus virus (HPV) infection (i.e., types 16, 18, 6, and 11) and for known or potential risk factors associated with the infection, including sexual behavior (e.g., kissing, performing oral sex, or vaginal intercourse), demographic characteristics (e.g., age or race), and history of HPV or other sexually transmitted infections. Prior exposure to HPV vaccine is also assessed. Oral rinse samples are collected from participants at baseline and at 6 months for detection of HPV genomic DNA in oral exfoliated cells. Baseline serum samples are also collected.

Conditions

• Head and Neck Cancer
• Infection
• Precancerous Condition

Interventions

Type	Name	Description
GENETIC	comparative genomic hybridization
GENETIC	gene expression analysis
OTHER	study of socioeconomic and demographic variables
PROCEDURE	evaluation of cancer risk factors
PROCEDURE	study of high risk factors

Timeline

• Start date: 2007-05-01
• Primary completion: 2009-05-01
• Completion: 2009-05-05
• First posted: 2009-05-12
• Last updated: 2019-01-17