NCT00846573

Hyperpolarized Noble Gas MR Imaging for Pulmonary Disorders

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: University of Massachusetts, Worcester · Academic / Other
• Sex: All
• Age: 5 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to test the efficacy of Hyperpolarized Helium-3 gas in MR imaging in COPD, asthmatics, CF and healthy volunteers.

Detailed description

Current pulmonary imaging techniques are clinically regulated to machines that produce radiation. MR which does not produce radiation was not possible due to the low concentration of fluids in the open spaces of the lungs. With hyperpolarized noble gases we can now use the safe techniques of MR imaging to view the airways of the lungs, thus limiting human exposure to radiation. This technique has already been proven to be possible in human subjects but there is insufficient data show its efficacy in a clinical setting. This study is designed to image a variety of pulmonary disorders to better find possible clinical uses for hyperpolarized gas MRI.

Conditions

• COPD
• Cystic Fibrosis
• Asthma
• Healthy

Interventions

Type	Name	Description
DRUG	Hyperpolarized Helium-3	Patients will be required to breath in individual 1 liter bags of gas while in an MRI to produce lung images. These bags of gas are each made up of 333mL of Helium-3 gas and 667mL of Nitrogen. Three bags will be administered to acquire three different scans.

Timeline

• Start date: 2008-11-01
• Primary completion: 2011-04-01
• Completion: 2011-04-01
• First posted: 2009-02-18
• Last updated: 2012-11-15
• Results posted: 2012-11-09

Locations

1 site across 1 country: United States