NCT00824824

Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Massachusetts Eye and Ear Infirmary · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

We have completed a study in which we examined the response of the retinal circulation to changes in posture from sitting to lying down in patients with primary open angle glaucoma (POAG). This alteration in position produces changes in the local blood pressure at the entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by dilating and constricting in order to maintain a steady blood flow rate. In an eye with POAG, this often does not occur. As a result, there are large fluctuations in blood flow which may produce the retinal neuronal damage associated with glaucoma. The purpose of this study is to demonstrate that topical anti-glaucoma treatments with agents that have vasoactive as well as IOP-lowering effects can have a beneficial effect on maintaining a steady retinal blood flow rate even when there are changes in local blood pressure.

Conditions

• Glaucoma

Interventions

Type	Name	Description
DRUG	Dorzolamide 2%-timolol 0.5%	BID OU for 6 weeks
DRUG	Brimonidine 0.2%-0.5% timolol 0.5	BID OU for 6 weeks

Timeline

• Start date: 2009-01-01
• Primary completion: 2012-08-01
• Completion: 2012-08-01
• First posted: 2009-01-19
• Last updated: 2017-04-04
• Results posted: 2016-10-28

Locations

1 site across 1 country: United States