NCT00789074

Use of Varenicline for 4-weeks Prior to Quitting

Effects of an Extended Period of Varenicline Use Prior to Quitting Smoking on Post-quitting Urges to Smoke

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: Queen Mary University of London · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Varenicline (Champix) is a relatively new medicine that is effective in helping people to quit smoking. It is normally started 1-week before stopping smoking and used for up to 12-24 weeks. We are trying to find out if using varenicline for an extended time (4-weeks) before stopping smoking is better than the standard 1-week of use prior to stopping. The study will recruit 100 smokers who want to stop. They will be randomly allocated to receive varenicline(4-weeks) or placebo (3-weeks followed by 1-week of active treatment as indicated by standard prescribing practice), followed by a 12-week open label treatment period where all participants will receive varenicline.

Conditions

• Tobacco Dependence
• Smoking Cessation

Interventions

Type	Name	Description
DRUG	Varenicline	Varenicline 1mg twice daily
DRUG	Placebo	Placebo 1mg BD

Timeline

• Start date: 2009-07-01
• Primary completion: 2009-12-01
• Completion: 2010-03-01
• First posted: 2008-11-11
• Last updated: 2013-12-12
• Results posted: 2012-06-25

Locations

1 site across 1 country: United Kingdom