NCT00617435

Impact of Trans Fatty Acids From Natural and Industrial Origin in the Induction of Insulin Resistance Development

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 66 (estimated)
• Sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The investigators' project has as for principal objective to understand the impact of trans fatty acids from dairy products and industrial origin on the development of insulin resistance in obese woman. Because of the different isomeric position of the double bound those trans fatty acids may have different metabolic effects.

Detailed description

Women will be included in the study according to their susceptibility to develop a insulin resistance (evaluated starting from the body index of mass IMC superior to 28 kg.m-², of the waist measurement 88 cm). Once included in the study, the volunteers will receive for 4 weeks butter, dairy products and biscuits enriched in stearic, elaidic or vaccenic acid. The volunteers will undergo a measurement of the body composition by biphotonic absorptiometry as well as a complete metabolic assessment (blood and urinary samples, clamp to insulin and biopsies).

Conditions

• Insulin Resistance
• Obesity

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	vaccenic acid enriched diet	The experimental milk fat, entitled "vaccenic acid enriched milk fat" (VAMF), has been obtained by feeding cows with a diet containing sunflower oil.
DIETARY_SUPPLEMENT	Elaidic acid enriched diet	Mixture of vegetable oils (including partially hydrogenated oils)
DIETARY_SUPPLEMENT	control diet	Mixed of different oil

Timeline

• Start date: 2007-10-01
• Primary completion: 2007-12-01
• Completion: 2009-01-01
• First posted: 2008-02-18
• Last updated: 2025-11-24

Locations

2 sites across 1 country: France