NCT00510705

Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: University of Leipzig · Academic / Other
• Sex: Male
• Age: 35 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by regular physical exercise training alone or in combination with a medical therapy (glitazone or metformin) in obese patients with severe coronary artery disease (CAD) and impaired glucose tolerance.

Conditions

• Severe Coronary Artery Disease
• Obesity
• Impaired Glucose Tolerance

Interventions

Type	Name	Description
OTHER	exercise training	physical exercise training on a bicycle ergometer daily for 4 weeks
OTHER	exercise training + metformin	physical exercise training on a bicycle ergometer + metformin (2 x 850 mg) daily for 4 weeks
OTHER	exercise training + glitazone	physical exercise training on a bicycle ergometer + glitazone daily for 4 weeks

Timeline

• Start date: 2007-07-01
• Primary completion: 2012-07-01
• First posted: 2007-08-02
• Last updated: 2020-11-27

Locations

1 site across 1 country: Germany