Trials / Unknown
UnknownNCT00497887
Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study
Observational Study for Identification of Genetic- and Biological-Markers of Predisposition to Atherosclerosis: Leipzig-Heart Study (LE-Heart)
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 4,000 (estimated)
- Sponsor
- University of Leipzig · Academic / Other
- Sex
- All
- Age
- 18 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
Atherosclerotic cardiovascular disease is the major cause of morbidity and mortality in Western societies. It is a complex genetic disorder with many genes involved and significant gene-environment interactions. The aim of the study is to identify novel genetic- and biological-markers of atherosclerosis. Atherosclerosis is assessed in the coronary arteries using coronary angiography as well as in the carotid artery (intima-media-thickness) and peripheral vessels (ankle brachial index). Association analysis of genetic and metabolic markers with atherosclerotic burden will be performed to identify novel factors of disposition to atherosclerotic vascular disease.
Conditions
- Atherosclerosis
- Coronary Arteriosclerosis
- Carotid Artery Diseases
- Genetic Predisposition to Disease
- Biological Markers
Timeline
- Start date
- 2006-12-01
- First posted
- 2007-07-09
- Last updated
- 2010-10-19
Locations
2 sites across 1 country: Germany
Source: ClinicalTrials.gov record NCT00497887. Inclusion in this directory is not an endorsement.