NCT00344058

Abbreviated MgSO4 Therapy in Post-partum Preeclampsia

Abbreviated Post-partum Magnesium Sulfate Seizure Prophylaxis in Preeclampsia: A Comparison of 12 and 24 Hour Regimens

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (planned)
• Sponsor: Case Western Reserve University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Magnesium sulfate is used for seizure prophylaxis in pregnancies complicated by preeclampsia. There is debate as to how long to continue this therapy after delivery of the pregnancy. Different schemes have been offered to shorten the exposure to magnesium sulfate after delivery, with little data. We seek to investigate the effect of shortened magnesium sulfate therapy on the post-partum recovery phase of mild preeclampsia. Our hypothesis was that shortened therapy (12 hours versus the traditional 24 hours post-partum) has no effect on disease course, and will result in significantly shorter exposure to magnesium sulfate.

Detailed description

The study has been completed at this time. Consenting women with suspected mild preeclampsia (new onset/exacerbated hypertension with proteinuria) were randomly assigned 12 (12-hour) or 24-hours (24-hour) of postpartum MgSO4. Treatment was continued beyond the initially assigned time period for new findings of severe preeclampsia. Clinical and laboratory data were collected. Analysis was by intent to treat, utilizing Fisher's exact, chi-square, and Student's t-tests where appropriate

Conditions

• Pregnancy
• Preeclampsia

Interventions

Type	Name	Description
DRUG	abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)

Timeline

• Start date: 2001-01-01
• Primary completion: 2004-08-01
• Completion: 2004-08-01
• First posted: 2006-06-26
• Last updated: 2025-09-10

Locations

1 site across 1 country: United States