NCT00312455

Effects of Fatty Acid Supplementation on Substance Dependent Individuals

Cholesterol and Fatty Acids in Cocaine Addiction Relapse

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: —
• Sponsor: National Institute on Drug Abuse (NIDA) · NIH
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Many substance dependent individuals continue to abuse a variety of substances during treatment for their disorder. Often, substance dependent individuals are co-diagnosed with depression and violence problems. Supplements of n-3 polyunsaturated fatty acids (PUFAs) may play a role in treating individuals with such substance abuse problems. The purpose of this study is to evaluate the effectiveness of the n-3 PUFAs eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) in treating relapse, aggression, and depression in substance dependent individuals.

Detailed description

Past research suggests that low levels of some PUFAs play a role in the pathophysiology of depressive and aggressive disorders. In addition, there is also evidence that PUFAs play a role in treating substance dependent individuals. The purpose of this study is to determine the efficacy of EFA and DPA in treating substance dependent individuals. Participants will be randomly assigned to receive either 3 grams of n-3 PUFAs or placebo. Treatment will last 3 months, followed by an observation period of 3 months. Study visits will occur monthly and will last approximately one hour. Study visits will include blood tests and a physical exam. Throughout the study, participants will continue to receive standard substance abuse treatment and will complete urine tests at regular intervals.

Conditions

• Substance-related Disorders

Interventions

Type	Name	Description
DRUG	Pro-eicosapentaenoic acid (EPA)	450 mg 5x/day
DRUG	Pro-docosapentaenoic acid (DPA)	100mg 5x/day
DRUG	Placebo	5 capsules/day

Timeline

• Start date: 2004-07-01
• Primary completion: 2005-07-01
• Completion: 2005-07-01
• First posted: 2006-04-10
• Last updated: 2017-01-12