NCT00311662

Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache

Multi-centre, Parallel Group, Double-blind, Placebo Controlled Study of the Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 124 (actual)
• Sponsor: Minster Research Ltd · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Overall trial objectives: * Can treatment with tonabersat reduce the number of days with a migraine headache in patients who suffer from frequent migraine attacks * How well tolerated is treatment with tonabersat The study is based on the hypothesis that the unique mechanism of action of tonabersat will inhibit some of the early events in the generation of migraine and so be effective as prophylactic treatment

Conditions

• Migraine Without Aura
• Migraine With Aura

Interventions

Type	Name	Description
DRUG	Tonabersat	Tablet 40mg daily for 12 weeks
DRUG	Placebo	Tablet once daily for 12 weeks

Timeline

• Start date: 2006-04-01
• Primary completion: 2006-10-01
• Completion: 2006-10-01
• First posted: 2006-04-06
• Last updated: 2009-08-31

Locations

17 sites across 4 countries: Denmark, Hungary, South Africa, United Kingdom