NCT00247819

The Genetic Basis for Vulnerability to Substance Abuse

Allelic Linkage in Substance Abuse

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8,000 (estimated)
• Sponsor: National Institute on Drug Abuse (NIDA) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This investigation seeks to better define the genetic basis for vulnerability to substance abuse.

Detailed description

Dopamine (DA), a neurotransmitter helping to mediate reward and reinforcement, has been putatively linked to the development of substance abuse, alcohol abuse, and alcoholism. Identification of specific vulnerability-association alleles for receptors, other molecules within the reward mediating system, and other genes that may predispose individuals to the development of such disorders is the goal of the study. This investigation will help elucidate the genetic underpinnings of substance abuse, potentially leading to the improved methods to diagnose those at risk and to help develop better therapeutic interventions.

Conditions

• Substance Abuse

Interventions

Type	Name	Description
PROCEDURE	Blood draw

Timeline

• Start date: 1992-08-01
• Primary completion: 2006-02-01
• Completion: 2006-02-01
• First posted: 2005-11-02
• Last updated: 2017-01-12

Locations

1 site across 1 country: United States