NCT00218569

Combined Treatment for Cocaine-Alcohol Dependence - 1

Combined Treatment for Cocaine-Alcohol Dependence

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 87 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine whether Naltrexone and cognitive behavioral therapy can be helpful in patients who want to stop using cocaine and alcohol.

Detailed description

This is a randomized, double blind placebo-controlled trial to examine the role of Relapse Prevention (RP) and Contingency Management (CMP) combined with Naltrexone (NTX) for the treatment of cocaine-alcohol dependence. Patients will be randomly assigned to NTX (100mg/d) or placebo combined with one of two psychotherapy conditions (RP or RP +CMP). Following a standardized consent and intake procedure patients will participate in a 12-week trial with thrice weekly visits. Manual-guided RP therapy will be delivered in weekly 60-minute individual sessions. CMP will be based on cocaine-negative urine screens and negative breath alcohol tests. Follow-up assessments will be conducted at 3 and 6 months after treatment.

Conditions

• Alcohol Dependence
• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	Naltrexone	Naltrexone
DRUG	Placebo	Placebo

Timeline

• Start date: 2003-04-01
• Primary completion: 2007-12-01
• Completion: 2007-12-01
• First posted: 2005-09-22
• Last updated: 2016-01-27

Locations

1 site across 1 country: United States