NCT00178581

Enteral Glutamine Supplementation for the Patient With Major Torso Trauma

Early Enteral Glutamine Supplement to Enteral Nutrition Support of the Major Torso Trauma Patient: Proposal for a Prospective Randomized Clinical Trial

• Status: Terminated
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 20 (planned)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.

Detailed description

In this prospective, randomized, controlled trial of patients with major torso trauma, high-dose enteral glutamine and enteral nutrition will be given to research subjects while controls will receive isocaloric, isonitrogenous enteral support. Enteral tolerance, bowel integrity and permeability will be evaluated. The systemic appearance of glutamine will be measured.

Conditions

• Trauma
• Critical Illness
• Shock

Interventions

Type	Name	Description
DRUG	Glutamine

Timeline

• Start date: 2005-06-01
• Completion: 2006-09-01
• First posted: 2005-09-15
• Last updated: 2010-04-23

Locations

1 site across 1 country: United States