Trials / Completed
CompletedNCT00000288
Role of Metabolites in Nicotine Dependence (2) - 5
Role of Metabolites in Nicotine Dependence (2)
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 0 (planned)
- Sponsor
- National Institute on Drug Abuse (NIDA) · NIH
- Sex
- All
- Age
- 21 Years – 45 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine the effects of varying doses of cotinine on cigarette self-administration.
Detailed description
Previous studies have shown that cotinine, a metabolite of nicotine, antagonizes some of the effects of nicotine. One study showed that nicotine eliminates some of the beneficial effects of the nicotine patch in reducing withdrawal symptoms. The purpose of this study was to examine the effects of cotinine. The results generally showed no effects on self-administration of cigarettes, although higher serum nicotine levels were observed on the highest doses of cotinine compared to placebo or lower doses of cotinine.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Cotinine fumarate |
Timeline
- Start date
- 1995-12-01
- Completion
- 2002-12-01
- First posted
- 1999-09-21
- Last updated
- 2017-01-12
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00000288. Inclusion in this directory is not an endorsement.