NCT00000273

A Laboratory Model for Heroin Abuse Medications - 8

A Laboratory Model for Heroin Abuse Medications

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the effects of treatment medications (methadone, buprenorphine, LAAM, naltrexone, naltrexone microcapsules, and methoclocinnamox) on I.V. and smoked heroin self-administration."

Detailed description

Abuse of prescription opioid medications has increased dramatically in the U.S. during the past decade, as indicated by a variety of epidemiological sources. However, few studies have systematically examined the relative reinforcing effects of commonly abused opioid medications. The current inpatient study was designed to compare the effects of intravenously delivered fentanyl , oxycodone, morphine, buprenorphine and heroin in morphine-maintained heroin abusers. All of the participants received all of the drugs tested; drugs and doses were administered in non-systematic order.

Conditions

• Heroin Dependence
• Opioid-Related Disorders
• Substance-Related Disorders

Interventions

Type	Name	Description
DRUG	opiates	prescription opioids

Timeline

• Start date: 1995-08-01
• Primary completion: 2005-11-01
• Completion: 2005-11-01
• First posted: 1999-09-21
• Last updated: 2017-07-05

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study