| Terminated | Combining Neuro-Imaging and Non-Invasive Brain Stimulation for Clinical Intervention in Opioid Use Disorder NCT04495673 | University of Minnesota | N/A |
| Unknown | Efficacy of Repetitive Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy on Heroin Dependence NCT03922659 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | N/A |
| Unknown | Laser Meridian Massage in Heroin Addicts NCT04003077 | Chang Gung Memorial Hospital | N/A |
| Terminated | Buprenorphine Stabilization and Induction Onto Vivitrol for Heroin-dependent Individuals NCT03711318 | New York State Psychiatric Institute | Phase 3 |
| Unknown | Repetitive Transcranial Magnetic Stimulation in Patients With Opioid Use Disorders NCT03229642 | National Cheng-Kung University Hospital | N/A |
| Completed | Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence NCT03015246 | Wayne State University | Phase 1 / Phase 2 |
| Completed | Change the Cycle: An RCT to Prevent Injection Initiation NCT02774954 | University of Southern California | N/A |
| Completed | Methadone Induced Memory Retrieval-extinction Procedure in Heroin Addicts NCT04133974 | National Institute on Drug Dependence, China | N/A |
| Unknown | Methadone Maintenance Outcome Study in Taiwan: 5-year Follow-up NCT02524912 | National Health Research Institutes, Taiwan | — |
| Unknown | University of Houston Drug Abuse Research Development Program II NCT03557632 | University of Houston | N/A |
| Completed | Extended-Release Naltrexone Opioid Treatment at Jail Re-Entry NCT01999946 | NYU Langone Health | Phase 4 |
| Unknown | Mirtazapine as a Treatment for Co-Occurring Opioid and ATS Dependence in Malaysia NCT02541526 | Universiti Sains Malaysia | Phase 3 |
| Unknown | An Open-label Study of Oral Paliparidone for the Treatment of Patients With Co-occurring Opioid and ATS Depend NCT02541513 | Universiti Sains Malaysia | Phase 3 |
| Unknown | An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Depende NCT02541500 | Universiti Sains Malaysia | Phase 3 |
| Completed | Economic Evaluation Comparing CCT With MMT in Hai Phong City, Vietnam NCT03071315 | The University of New South Wales | — |
| Completed | Depot Naltrexone Mechanism of Action in Heroin Dependent Patients Using fMRI and SPECT NCT01471145 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 4 |
| Completed | Diversion to Treatment for Injection Drug Users Arrested for Possession of Heroin NCT01723527 | Johns Hopkins University | Phase 1 |
| Completed | Studies of Opioid Seeking Behavior: Yohimbine and Hydrocortisone Effects NCT01536925 | Wayne State University | — |
| Completed | Study to Assess Longer-term Opioid Medication Effectiveness (SALOME) NCT01447212 | University of British Columbia | Phase 3 |
| Completed | Biomarkers of Injectable Extended Release Naltrexone Treatment NCT02324725 | University of Pennsylvania | Phase 4 |
| Terminated | Pioglitazone for Heroin and for Nicotine Dependence NCT01395797 | New York State Psychiatric Institute | Phase 1 / Phase 2 |
| Completed | Study of Computer-Based Treatment for Drug Dependence NCT01315184 | Yale University | Phase 2 |
| Unknown | Effect Study of Optimized Intervention to Heroin Addicts NCT01144390 | Shanghai Mental Health Center | N/A |
| Completed | Reinforcing Effects of Intranasal (IN) Buprenorphine Versus Buprenorphine/Naloxone NCT01760473 | New York State Psychiatric Institute | Phase 3 |
| Completed | Pharmacogenomics Study of Sleep Disturbance and Neurocognitive Impairments in the Opioid Addicts NCT01668706 | National Health Research Institutes, Taiwan | — |
| Completed | Variance of Oral Methadone Dosage: Description of Implicated Factors NCT00894452 | Assistance Publique - Hôpitaux de Paris | — |
| Withdrawn | Directly Administered Antiretroviral Therapy (DAART) Among HIV-1infected Injecting Drug Users (IDUs) in Chenna NCT00709007 | Johns Hopkins University | Phase 2 / Phase 3 |
| Completed | Memantine as a Supplement to Naltrexone in Treating Heroin Dependence NCT00476242 | New York State Psychiatric Institute | Phase 2 / Phase 3 |
| Completed | Treatment Study: Reducing Cocaine/Heroin Abuse With SR-Amphetamine and Buprenorphine (ARC) NCT00698737 | Wayne State University | — |
| Unknown | Community Reinforcement and Family Training for Drug Abuse Treatment Retention/HIV Risk Reduction NCT00609089 | University of Cincinnati | Phase 1 / Phase 2 |
| Completed | Effects of Stress and Other Factors on Opiate Drug Choice. NCT00684840 | Wayne State University | — |
| Unknown | Ability of Aprepitant to Block Opioid Reward in Non-Dependent Opiate Abusers NCT00726960 | Karolinska University Hospital | Phase 1 |
| Completed | Buprenorphine Maintenance Treatment of Opioid Dependence in Primary Care: A Randomized Clinical Trial NCT00684554 | New York State Psychiatric Institute | Phase 2 / Phase 3 |
| Completed | Behavioral Naltrexone Therapy for Promoting Adherence to Oral Naltrexone vs Extended Release Injectable Depot NCT00577408 | New York State Psychiatric Institute | Phase 3 |
| Completed | Effects of Environmental Factors on Opiate Drug Choice in Opioid Dependent Individuals. NCT00608504 | Wayne State University | — |
| Completed | Effect of Stress on Heroin-Related Memory Retrieval NCT00759005 | National Institute on Drug Dependence, China | N/A |
| Completed | Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individ NCT00429767 | Wayne State University | — |
| Completed | Addiction Treatment in Russia: Oral vs. Naltrexone Implant NCT00218426 | University of Pennsylvania | Phase 2 / Phase 3 |
| Completed | Study of Buprenorphine Maintenance Treatment for Opioid Dependence in Primary Care NCT00471042 | New York State Psychiatric Institute | — |
| Completed | Directly Administered HIV Therapy in Methadone Clinics NCT00279110 | Johns Hopkins University | Phase 2 / Phase 3 |
| Completed | Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts NCT00142948 | Baylor College of Medicine | Phase 2 |
| Completed | Employment-based Reinforcement of Naltrexone Ingestion and Abstinence NCT00149669 | Johns Hopkins University | N/A |
| Completed | Effects of Post-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals NCT00218361 | Wayne State University | — |
| Completed | A Stepwise Strategy Utilizing Buprenorphine and Methadone NCT00310934 | Karolinska University Hospital | Phase 4 |
| Completed | Addition of Naltrexone to Methadone Taper NCT00135759 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Skills Based Counseling for Adherence and Depression in HIV+ Methadone Patients - 1 NCT00218634 | Massachusetts General Hospital | N/A |
| Completed | Effects of Pre-Session Supplemental Hydromorphone on Drug Seeking Behavior in Opioid Dependent Individuals NCT00218309 | National Institute on Drug Abuse (NIDA) | — |
| Completed | Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1 NCT00249574 | National Institute on Drug Abuse (NIDA) | N/A |
| Completed | The Therapeutic Workplace Initiation Study NCT00249470 | Johns Hopkins University | N/A |
| Completed | Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1 NCT00218530 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-3 - 6 NCT00000331 | University of Colorado, Denver | Phase 2 |
| Completed | Effects of Buspirone in Opiate Withdrawal NCT00326235 | National Institute on Drug Abuse (NIDA) | Phase 4 |
| Completed | Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens NCT00218127 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1 NCT00032955 | University of California, Los Angeles | Phase 3 |
| Completed | Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1 NCT00032968 | University of California, Los Angeles | Phase 3 |
| Completed | Counseling Conditions for Buprenorphine in a Primary Care Clinic - 1 NCT00023283 | Yale University | Phase 2 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5 NCT00000330 | University of Colorado, Denver | Phase 2 |
| Completed | Opiate Dependence: Combined Naltrexone/Behavior Therapy - 1 NCT00238914 | New York State Psychiatric Institute | Phase 2 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-1 - 4 NCT00000329 | University of Colorado, Denver | Phase 2 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment III) - 3 NCT00000328 | University of Colorado, Denver | Phase 2 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment I(2) - 2 NCT00000327 | University of Colorado, Denver | Phase 2 |
| Withdrawn | Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment 1 - 1 NCT00000326 | University of Colorado, Denver | Phase 2 |
| Completed | The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Coc NCT00158288 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Buprenorphine and Naloxone Combination Study - 10 NCT00015288 | National Institute on Drug Abuse (NIDA) | Phase 1 |
| Completed | Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2 NCT00249457 | Johns Hopkins University | N/A |
| Completed | Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1 NCT00015171 | National Institute on Drug Abuse (NIDA) | Phase 3 |
| Completed | A Laboratory Model for Heroin Abuse Medications - 8 NCT00000273 | New York State Psychiatric Institute | Phase 2 |
| Completed | Treatment Efficacy for Drug Abuse and AIDS Prevention - 1 NCT00000210 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Treatment Efficacy for Drug Abuse and AIDS Prevention - 2 NCT00000211 | National Institute on Drug Abuse (NIDA) | Phase 2 |
| Completed | Study Comparing Liquid and Tablet Buprenorphine Formulations - 5 NCT00000302 | National Institute on Drug Abuse (NIDA) | Phase 3 |