| Not Yet Recruiting | A Study of Alisertib and Paclitaxel in Patients With Small Cell Lung Cancer (SCLC) Small Cell Lung Cancer ( SCLC ) | Phase 2 | 2026-09-30 |
| Recruiting | A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurre Hormone Receptor Positive HER-2 Negative Breast Cancer, Metastatic Breast Cancer, Recurrent Breast Cancer | Phase 2 | 2024-11-19 |
| Recruiting | A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer Small Cell Lung Cancer | Phase 2 | 2024-02-08 |
| Completed | A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With Neratinib HER2 Amplified Breast Cancer | Phase 2 | 2020-06-30 |
| Terminated | HER-Seq: A Blood-based Screening Study to Identify Patients With HER2 Mutations for Enrollment Into Clinical R Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer, Metastatic Cervical Cancer | — | 2019-03-14 |
| Completed | An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Early Stage HER2+ Breast Cancer | Phase 2 | 2015-02-01 |
| Completed | Open-label PK Study to Evaluate Lansoprazole and Neratinib in Healthy Subjects Healthy | Phase 1 | 2014-08-01 |
| Terminated | Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations | Phase 2 | 2013-09-30 |
| Completed | Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Can HER2-mutant Non-Small Cell Lung Cancer | Phase 2 | 2013-07-01 |
| Completed | A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Br HER2+ Metastatic Breast Cancer (MBC) | Phase 3 | 2013-03-29 |
| Withdrawn | Study Evaluating The Effect Of A High-Fat Meal On The Pharmacokinetics Of Neratinib Healthy | Phase 1 | 2012-08-01 |
| Completed | A Single Dose Bioequivalence Study Of Neratinib In Healthy Subjects Healthy | — | 2010-06-01 |
| Completed | A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid Tumor Advanced Malignant Solid Tumors | Phase 1 | 2010-04-01 |
| Completed | Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer Breast Cancer | Phase 1 / Phase 2 | 2010-04-01 |
| Completed | Study Evaluating Neratinib Plus Paclitaxel VS Trastuzumab Plus Paclitaxel In ErbB-2 Positive Advanced Breast C Breast Cancer | Phase 2 | 2009-08-21 |
| Completed | Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer Breast Cancer | Phase 3 | 2009-07-09 |
| Completed | Study Evaluating Neratinib In Combination With Vinorelbine In Subjects With Advanced Or Metastatic Solid Tumor Advanced Malignant Solid Tumors | Phase 1 | 2009-07-01 |
| Completed | Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease Hepatic Insufficiency | Phase 1 | 2009-04-01 |
| Completed | Study Evaluating The Potential Effect Of Rifampin On The Pharmacokinetics Of Neratinib Healthy Subjects | Phase 1 | 2009-04-01 |
| Completed | Study Evaluating Neratinib In Combination With Temsirolimus In Subjects With Solid Tumors Neoplasms, Malignant Carcinoma | Phase 1 | 2009-04-01 |
| Completed | Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Healthy | Phase 1 | 2009-04-01 |
| Completed | Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer Advanced Breast Cancer, Breast Cancer | Phase 2 | 2009-02-04 |
| Completed | Study Evaluating TwoTablet Formulations of Neratinib (HKI-272) Healthy Subjects | Phase 1 | 2009-01-01 |
| Completed | Study Evaluating The Combination Of Neratinib And Capecitabine In Solid Tumors And Breast Cancer Breast Cancer | Phase 1 / Phase 2 | 2008-12-09 |
| Completed | Study Evaluating Safety And Tolerability, Solid Tumor Advanced Malignant Solid Tumors | Phase 1 | 2008-10-01 |
| Completed | Study Evaluating The Tolerability Of Multiple Doses Of HKI-272 Healthy Subjects | Phase 1 | 2008-10-01 |
| Completed | Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization) Breast Cancer | Phase 1 | 2008-05-01 |
| Completed | Study Evaluating Neratinib (HKI-272) In Combination With Vinorelbine In Subjects With Solid Tumors And Metasta Breast Cancer, Advanced Malignant Solid Tumors | Phase 1 / Phase 2 | 2008-04-29 |
| Completed | Study Evaluating Oral Administrations of HKI-272 in Healthy Male Subjects Healthy | Phase 1 | 2008-03-01 |
| Completed | A Phase 1/2 Study of HKI-272 (Neratinib) in Combination With Paclitaxel (Taxol) in Subjects With Solid Tumors Advanced Breast Cancer, Advanced Malignant Solid Tumors, Breast Neoplasms | Phase 1 / Phase 2 | 2007-09-11 |
| Completed | Study Comparing 2 New Formulations of HKI-272 in Healthy Adult Subjects Healthy | Phase 1 | 2007-07-01 |
| Completed | A Phase 1/2 Study Of HKI-272 (Neratinib) in Combination With Trastuzumab (Herceptin) In Subjects With Advanced Advanced Breast Cancer | Phase 1 / Phase 2 | 2007-04-04 |
| Completed | A Study Of The Safety And Tolerability Of HKI-272 Administered Orally To Japanese Subjects With Advanced Solid Tumors | Phase 1 | 2006-11-01 |
| Completed | HKI-272 Ketoconazole Drug Interaction Study Healthy | Phase 1 | 2006-10-01 |
| Completed | Study Evaluating HKI-272 (Neratinib) In Subjects With Advanced Breast Cancer Breast Neoplasms, Neoplasms | Phase 2 | 2006-08-04 |
| Completed | Study Evaluating HKI-272 Administered to Healthy Subjects Healthy | Phase 1 | 2006-07-01 |
| Completed | Study Evaluating the Safety Of HKI-272 (Neratinib) In Subjects With Advanced Non-Small Cell Lung Cancer Carcinoma, Non-Small-Cell Lung, Lung Neoplasms | Phase 2 | 2005-12-01 |
| Completed | Study Evaluating HKI-272 in Tumors Breast Neoplasms | Phase 1 | 2003-11-01 |