| Recruiting | ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response Major Depressive Disorder (MDD), Depressive Disorder, Treatment-Resistant | Phase 2 | 2025-11-14 |
| Enrolling By Invitation | Phase 3, Open Label Extension Study of ACP-204 in Lewy Body Dementia Psychosis Lewy Body Dementia Psychosis | Phase 3 | 2025-11-14 |
| Recruiting | Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis Lewy Body Dementia Psychosis | Phase 2 | 2025-08-06 |
| Enrolling By Invitation | ACP-204 in Adults With Alzheimer's Disease Psychosis Open Label Extension Study Alzheimer's Disease Psychosis | Phase 3 | 2024-04-23 |
| Enrolling By Invitation | OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome Hyperphagia in Prader-Willi Syndrome | Phase 3 | 2024-03-11 |
| Active Not Recruiting | Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome Hyperphagia in Prader-Willi Syndrome | Phase 3 | 2023-11-27 |
| Recruiting | ACP-204 in Adults With Alzheimer's Disease Psychosis Alzheimer's Disease Psychosis | Phase 2 / Phase 3 | 2023-11-14 |
| Terminated | Extension Study of Pimavanserin in Irritability Associated With Autism Spectrum Disorder Irritability Associated With Autism Spectrum Disorder | Phase 2 / Phase 3 | 2022-11-02 |
| Completed | Pimavanserin for the Treatment of Irritability Associated With Autism Spectrum Disorder Irritability Associated With Autism Spectrum Disorder | Phase 2 / Phase 3 | 2022-08-09 |
| Terminated | An Open-Label Study of Trofinetide for the Treatment of Girls Two to Five Years of Age Who Have Rett Syndrome Rett Syndrome | Phase 2 / Phase 3 | 2021-09-22 |
| Terminated | Evaluate the Efficacy and Safety of ACP-044 in Subjects With Pain Associated With Osteoarthritis of the Knee Osteoarthritis Pain | Phase 2 | 2021-07-20 |
| Completed | Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionecto Acute Postoperative Pain, Bunionectomy | Phase 2 | 2021-03-29 |
| Terminated | Open-Label Extension Study of Trofinetide for Rett Syndrome Rett Syndrome | Phase 3 | 2020-11-08 |
| Completed | Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia Schizophrenia | Phase 3 | 2020-08-05 |
| Completed | Open-Label Study With Pimavanserin on Activities of Daily Living in Subjects With Parkinson's Disease Psychosi Parkinson Disease Psychosis | Phase 4 | 2020-02-10 |
| Completed | Open-Label Extension Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome Rett Syndrome | Phase 3 | 2020-01-29 |
| Completed | Study of Trofinetide for the Treatment of Girls and Women With Rett Syndrome (LAVENDER™) Rett Syndrome | Phase 3 | 2019-11-06 |
| Terminated | Study to Evaluate Safety and Daytime Sedation in Subjects With Parkinson's Disease With Neuropsychiatric Sympt Parkinson's Disease | Phase 2 | 2019-10-23 |
| Terminated | Extension Study of Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepr Adjunctive Treatment of Major Depressive Disorder | Phase 3 | 2019-06-06 |
| Completed | Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant T Adjunctive Treatment of Major Depressive Disorder | Phase 3 | 2019-04-25 |
| Completed | Extension Study of Pimavanserin in Adult Subjects With Neuropsychiatric Symptoms Related to Neurodegenerative Neuropsychiatric Symptoms Related to Neurodegenerative Disease | Phase 3 | 2018-07-17 |
| Completed | A Safety Study of Pimavanserin in Adult and Elderly Subjects Experiencing Neuropsychiatric Symptoms Related to Neuropsychiatric Symptoms Related to Neurodegenerative Disease | Phase 3 | 2018-05-21 |
| Completed | Safety and Efficacy of Pimavanserin in Adults With Parkinson's Disease and Depression Treatment of Depression in Adults With Parkinson's Disease (PD) | Phase 2 | 2018-03-09 |
| Completed | Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis Dementia-related Psychosis | Phase 3 | 2017-09-27 |
| Terminated | The INSYTE (Management of Parkinson's Disease Psychosis in Actual Practice) Study Parkinson Disease Psychosis | — | 2017-03-30 |
| Completed | A Study of Pimavanserin for the Treatment of Agitation and Aggression in Subjects With Alzheimer's Disease Agitation and Aggression in Alzheimer's Disease | Phase 2 | 2017-02-23 |
| Terminated | Extension Study of Pimavanserin for the Adjunctive Treatment of Schizophrenia Schizophrenia | Phase 3 | 2017-01-01 |
| Completed | Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder (CLARITY) Adjunctive Treatment of Major Depressive Disorder | Phase 2 | 2016-12-01 |
| Completed | Efficacy and Safety of Pimavanserin as Adjunctive Treatment for the Negative Symptoms of Schizophrenia (ADVANC Schizophrenia | Phase 2 | 2016-11-04 |
| Terminated | Study to Examine the Safety and Efficacy of Pimavanserin for the Treatment of Agitation and Aggression in Alzh Agitation and Aggression in Alzheimer's Disease | Phase 2 | 2016-11-01 |
| Completed | Efficacy and Safety of Adjunctive Pimavanserin for the Treatment of Schizophrenia (ENHANCE-1) Schizophrenia | Phase 3 | 2016-10-26 |
| Completed | A Study of the Safety and Efficacy of Pimavanserin in Patients With Alzheimer's Disease Psychosis Alzheimer's Disease Psychosis | Phase 2 | 2013-11-01 |
| Completed | A Study of the Safety and Efficacy of Pimavanserin in Patients With Parkinson's Disease Psychosis Parkinson's Disease Psychosis | Phase 3 | 2010-07-01 |
| Completed | A Study of Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis Parkinson's Disease Psychosis | Phase 3 | 2008-03-01 |
| Completed | A Study of the Safety and Tolerability of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosi Parkinson's Disease Psychosis | Phase 3 | 2007-07-01 |
| Completed | A Study of the Safety and Efficacy of Pimavanserin (ACP-103) in Patients With Parkinson's Disease Psychosis Parkinson's Disease Psychosis | Phase 3 | 2007-06-01 |
| Completed | ACP-104 in Acutely Psychotic Subjects With Schizophrenia Schizophrenia | Phase 2 | 2007-06-01 |
| Completed | Antipsychotic and Motor Effects of ACP-103 When Administered in Combination With Haloperidol and Risperidone Schizophrenia | Phase 2 | 2005-08-01 |
| Completed | An Open-label Safety Study of Pimavanserin in Parkinson's Disease Patients Parkinson's Disease Psychosis | Phase 2 | 2004-11-17 |
| Completed | Treatment of Hallucinosis/Psychosis in Parkinson's Disease by an Investigational Drug Hallucinations, Psychoses, Parkinson's Disease | Phase 2 | 2004-03-01 |
| Approved For Marketing | Expanded Access of Pimavanserin for Patients With PD Psychosis Parkinson's Disease Psychosis | — | — |