| Withdrawn | Multiregion BHA in Open Tibia Fractures NCT04056429 | Carmell Therapeutics Corporation | Phase 2 |
| Recruiting | Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Tibial Shaft Fractures NCT07092579 | Comeback Mobility Inc | N/A |
| Recruiting | Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibia NCT06679049 | University of Alabama at Birmingham | N/A |
| Recruiting | Blood Flow Restriction Training in Patients With Lower Extremity Fractures NCT06496035 | Denver Health and Hospital Authority | N/A |
| Not Yet Recruiting | Results of Cross-leg Free Vascularized Fibular Graft NCT06491316 | Assiut University | — |
| Recruiting | Intramedullary Calcium Sulfate Antibiotic Depot NCT05766670 | Wake Forest University Health Sciences | Phase 3 |
| Recruiting | Management of Closed Diaphyseal Displaced Leg Fractures in Children and Adolescents NCT06503718 | University Hospital, Strasbourg, France | — |
| Recruiting | Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Comp NCT05889559 | Major Extremity Trauma Research Consortium | N/A |
| Recruiting | Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial NCT05421741 | Wake Forest University Health Sciences | Phase 4 |
| Withdrawn | Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation NCT05317676 | University of California, Irvine | Phase 2 |
| Recruiting | Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures? NCT05652881 | United States Naval Medical Center, San Diego | N/A |
| Completed | Distal Targeter vs Free-hand NCT05613257 | Cedars-Sinai Medical Center | N/A |
| Unknown | Clinical Validation of the C-Arm Rotational View (CARV) to Avoid Rotational Malalignment After Intramedullary NCT05459038 | University Medical Center Groningen | N/A |
| Completed | Depuy Synthes Lower Extremity Shaft Nail Registry NCT05272631 | DePuy Synthes Products, Inc. | — |
| Recruiting | Zimmer® Natural Nail® (ZNN) Bactiguard Tibia Post-Market Clinical Follow-up Study NCT05022485 | Zimmer Biomet | — |
| Unknown | MRI Assessment of Cartilage Damage in Tibial Nailing NCT04831671 | Cambridge University Hospitals NHS Foundation Trust | N/A |
| Completed | Rehabilitation Strategies to Improve Outcomes For Patients With a Lower Extremity Fracture NCT05274022 | Brian W. Noehren | N/A |
| Recruiting | Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized NCT07006675 | Major Extremity Trauma Research Consortium | Phase 3 |
| Completed | Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Frac NCT04761302 | University of Puerto Rico | Phase 4 |
| Active Not Recruiting | Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® NCT04113044 | AO Innovation Translation Center | — |
| Completed | Posterior Plating Versus Anterior to Posterior Screws in Fixation of Posterior Column in Pilon Fractures NCT05303389 | Ain Shams University | N/A |
| Recruiting | Knee Osteoarthritis in the Region of Norrbotten NCT06451510 | Umeå University | — |
| Recruiting | Intramedullary Bone Grafting for Open Tibial Shaft Fractures NCT03891888 | University of Louisville | N/A |
| Unknown | Arthroscopic Assisted Balloon Tibioplasty for the Treatment of Schatzker II-IV Tibial Plateau Fractures NCT03327337 | Second Affiliated Hospital of Wenzhou Medical University | N/A |
| Withdrawn | Bone Healing Accelerant Versus Standard of Care for Open Tibia Fractures NCT03826784 | Carmell Therapeutics Corporation | Phase 3 |
| Terminated | Safety Study of Treatment of Leg Fractures NCT03881241 | Smith & Nephew, Inc. | — |
| Completed | A Post-Market Clinical Evaluation of the Treatment of Tibia Fractures With the T2 Alpha Tibia Nailing System NCT04015167 | Stryker Trauma and Extremities | — |
| Completed | Surgical Management of Posterior Tibial Plateau Fractures NCT03540719 | Harm Hoekstra, prof. dr. | — |
| Completed | Real Life Weight Bearing After Tibial Fractures NCT03166267 | AO Innovation Translation Center | — |
| Recruiting | Prosthesis Versus Osteosynthesis in Proximal Tibia Fractures NCT03172715 | Central Finland Hospital District | N/A |
| Unknown | Vitamin D Supplementation and Tibia Fracture. Does it Improve Healing Rate? NCT03232216 | Hospital del Trabajador de Santiago | N/A |
| Completed | INfrapatellar Versus SUprapatellar Reamed Intramedullary Nailing for Fractures of the Tibia NCT02750072 | Fraser Orthopaedic Research Society | N/A |
| Terminated | Comminuted Intra-Articular Distal Tibia Fracture Fixation Using Computer Techniques NCT02845245 | Inova Health Care Services | N/A |
| Terminated | Intra-articular Local Anesthetic Injection and Hematoma Aspiration NCT02951884 | Loyola University | Phase 4 |
| Not Yet Recruiting | Study of Prognostic Factors of the Distal Epiphysis of the Tibia Fracture Prognosis NCT02723825 | Foshan Hospital of Traditional Chinese Medicine | N/A |
| Enrolling By Invitation | Conjoint Analysis of Patient Preferences in Joint Interventions NCT02664337 | Duke University | N/A |
| Completed | Intramedullary Nailing Versus External Fixation in Open Tibia Fractures in Tanzania NCT03861624 | University of California, San Francisco | N/A |
| Completed | Safety and Performance of BonyPid-1000™ in the Treatment of Gustilo I, II, IIIA and IIIB Tibial Open Fractures NCT02491047 | PolyPid Ltd. | N/A |
| Completed | Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Cal NCT02456194 | Ross Leighton | N/A |
| Completed | Mobile Monitoring of Fracture Healing NCT02534259 | Milton S. Hershey Medical Center | — |
| Unknown | Virtual Reality for Tibial Eminence Fractures NCT04722081 | South Valley University | N/A |
| Unknown | Intra-op Monitoring With NIRS and NICOM, and Surgical Outcome in Elderly Patients With Fractures of Lower Limb NCT02280512 | National Taiwan University Hospital | — |
| Completed | Reliability of Sensor Spacing for NIRS in Traumatic Tibia Fractures NCT02301832 | Emory University | — |
| Completed | New Bone Fixation Plate for the Repair of Tibial Avulsion Fracture of Posterior Cruciate Ligament of the Knee NCT03059368 | Cangzhou Central Hospital | N/A |
| Completed | Immobilization Versus Observation in Children With Toddler's Fractures: a Prospective Randomized Controlled Tr NCT01926795 | Prisma Health-Upstate | N/A |
| Completed | Intramedullary Nailing of Tibia Fractures NCT01797640 | University of Utah | — |
| Terminated | rhBMP-2 Versus Autograft in Critical Size Tibial Defects NCT00853489 | St. Louis University | Phase 4 |
| Completed | Suprapatellar Versus Infrapatellar Nailing in Tibial Fractures: A Pilot Study NCT01341418 | Florida Orthopaedic Institute | N/A |
| Completed | Efficacy Study of Surgical Technique in Intramedullary Tibia Nailing, Using Trigen META Tibia Nails NCT01358292 | Smith & Nephew Orthopaedics AG | Phase 4 |
| Completed | Reamed Nailing Versus Taylor Spatial Frame in Tibia Shaft Fractures NCT03388879 | Oslo University Hospital | N/A |
| Completed | Distal Locking Using an Electromagnetic Field Guided Computer Based Real Time System for Orthopaedic Trauma Pa NCT01183078 | Wake Forest University Health Sciences | N/A |
| Withdrawn | Stem Cells and Tibial Fractures NCT00632034 | Imperial College London | N/A |
| Terminated | Reamed Locked Plating - Metaphyseal Fractures of the Distal Femur and Tibia NCT01553630 | Florida Orthopaedic Institute | N/A |
| Completed | Trial to Evaluate the Effectiveness of Angular Stable Locking System (ASLS) in Patients With Distal Tibial Fra NCT00875992 | AO Clinical Investigation and Publishing Documentation | N/A |
| Completed | Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures NCT01132508 | Synthes GmbH | — |
| Terminated | Trial to Evaluate UltraSound in the Treatment of Tibial Fractures NCT00667849 | Bioventus LLC | N/A |
| Completed | ACTiF- Assessment of Closed Tibial Fractures NCT00533377 | Pfizer | Phase 2 |
| Completed | Percutaneous Autologous Bone-marrow Grafting for Open Tibial Shaft Fracture NCT00512434 | University Hospital, Tours | N/A |
| Completed | A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures NCT00429585 | Boston Medical Center | N/A |
| Completed | Compartmental Overpressures Associated to Reamed Intramedullary Nails NCT00842101 | University of Andorra | — |
| Terminated | Light Therapy in the Treatment of Leg Pain NCT00253981 | Samueli Institute for Information Biology | N/A |
| Unknown | Pulsed Electromagnetic Field (PEMF) Stimulation for Tibia Fractures NCT00127725 | Sydney South West Area Health Service | Phase 2 |
| Completed | Study Evaluating InductOs in Diaphyseal Tibia Fractures NCT00161616 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 4 |