| Recruiting | Safety and Efficacy of ONT01 in Lupus NCT07107659 | Hospital for Special Surgery, New York | EARLY_Phase 1 |
| Not Yet Recruiting | Association of Serum Interleukin-33 Levels With Clinical Manifestations in Systemic Lupus Erythematosus NCT07149402 | Assiut University | — |
| Not Yet Recruiting | Efficacy and Safety of CRC01 in Participants With Severe, Refractory Systemic Lupus Erythematosus NCT07364396 | Curocell Inc. | Phase 1 / Phase 2 |
| Recruiting | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evalu NCT07260877 | Ventus Therapeutics U.S., Inc. | Phase 2 |
| Recruiting | A Study of Anti-CD19/BCMA Universal CAR-T Cell Therapy RD06-05 in Patients With Autoimmune Diseases. NCT07203404 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Not Yet Recruiting | Evaluating Mental Health Challenges in Juvenile Lupus Erythematosus and Their Caregivers NCT06581029 | Assiut University | — |
| Recruiting | CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus NCT06839976 | Children's Hospital of Philadelphia | Phase 1 / Phase 2 |
| Not Yet Recruiting | Assessment of Blood Indices in Systemic Lupus Erythematosus NCT06872086 | Assiut University | — |
| Recruiting | A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Systemic Lupu NCT06613360 | Cullinan Therapeutics Inc. | Phase 1 |
| Recruiting | UC-MSC Cell Therapy Study for Systemic Lupus Erythematosus (SLE) Patients NCT06737380 | LiveKidney.Bio | Phase 1 |
| Recruiting | Clinical Study on Targeted CD19/BCMA CAR-T Therapy for Autoimmune Diseases NCT06775912 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Withdrawn | Phase 1b/2a in SLE With Budoputug NCT06570434 | Tenet Medicines | Phase 1 / Phase 2 |
| Recruiting | Pregnancies Before the Diagnosis of Systemic Lupus Erythematosus NCT07148115 | University of Algiers | — |
| Enrolling By Invitation | Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases NCT06763783 | Region Skane | Phase 4 |
| Withdrawn | A Study of RD06-04 in Patients With Active Autoimmune Diseases NCT06548620 | Nanjing Bioheng Biotech Co., Ltd. | EARLY_Phase 1 |
| Recruiting | A Study of APG-2575 in Patients With Mild-to-moderate Systemic Lupus Erythematosus. NCT06182969 | Ascentage Pharma Group Inc. | Phase 1 / Phase 2 |
| Active Not Recruiting | AB-101 in Combination With B-Cell Depleting mAb in Patients Who Failed Treatment for Class III or IV Lupus Nep NCT06265220 | Artiva Biotherapeutics, Inc. | Phase 1 |
| Active Not Recruiting | Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases NCT05822219 | Northwestern University | N/A |
| Completed | SLE Severity Linked to Vitamin D Via Treg Cells in Pediatric Patients NCT07069348 | Wisnu Barlianto | — |
| Active Not Recruiting | Phase 2 Placebo-Controlled Study to Assess the Safety and Efficacy of ESK-001 in Active Systemic Lupus Erythem NCT05966480 | Alumis Inc | Phase 2 |
| Completed | Cardio Renal Effects of SGLT2 Inhibitors Among Lupus Nephritis Patients NCT05748925 | Mansoura University | Phase 4 |
| Unknown | Relation of Antibodies Against Oxidized Low Density Lipoproteins to Disease Activity and Cardiovascular Affect NCT05479071 | Assiut University | — |
| Unknown | Flow Mediated Dilation in Association With Hyperuricemia NCT05342285 | Assiut University | — |
| Unknown | Fetal-Hope Study: Home Monitoring of Fetal Heart Rate in SSA+ Pregnant Women NCT05958446 | ASST Fatebenefratelli Sacco | — |
| Recruiting | Argentinian Prospective Registry of Patients With Lupus NCT05470569 | Sociedad Argentina de Reumatologia | — |
| Unknown | Gynecological Symptoms and Health-related Quality of Life in Egyptian Women With SLE NCT05230316 | Fayoum University | — |
| Unknown | Serum IL 26 as a Marker of Disease Activity in SLE NCT05161988 | Assiut University | — |
| Completed | COVID-19 Vaccine in Immunosuppressed Adults With Autoimmune Diseases NCT04806113 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 3 |
| Unknown | A Study on Protein Losing Enteropathy In Systemic Lupus Erythematosus NCT04517240 | Assiut University | — |
| Completed | Telemedicine for Follow-up of Systemic Lupus Erythematosus NCT04368299 | Chinese University of Hong Kong | N/A |
| Unknown | Effect of Gender on Clinical Presentation of SLE ِAt Assiut University Hospitals NCT04234633 | Assiut University | — |
| Unknown | New Signaling Pathway Targeting Systemic Lupus Erythematosus NCT03984227 | Assiut University | — |
| Unknown | Translation of a Diagnostic Test for Lupus Flare Prediction From Bench to Clinic NCT04018222 | Progentec Diagnostics, Inc. | — |
| Completed | Choosing Tests Wisely in Rheumatology NCT03240536 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | JBT-101 in Systemic Lupus Erythematosus (SLE) NCT03093402 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | Does Balnotherapy Influence the Qualitiy of Life in SLE NCT04392791 | Polyclinic of the Hospitaller Brothers of St. John of God, Budapest | N/A |
| Completed | Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus NCT03142711 | Lupus Research Alliance | — |
| Completed | Improving the Assessment of SLE Disease Activity NCT03144063 | University Health Network, Toronto | — |
| Completed | Effect Of Curcuma Xanthorrhiza and Vitamin D3 Supplementation in SLE Patients With Hypovitamin D NCT03155477 | Saiful Anwar Hospital | N/A |
| Terminated | 3,3'-Diindolylmethane in Patients With Systemic Lupus Erythematosus NCT02483624 | Northwell Health | Phase 1 |
| Terminated | Randomized MMF Withdrawal in Systemic Lupus Erythematosus (SLE) NCT01946880 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Unknown | Premature Atherosclerosis in Systemic Lupus Erythematosus NCT04037293 | Peking Union Medical College Hospital | — |
| Active Not Recruiting | Myocardial Inflammation in Systemic Lupus Erythematosus NCT01761422 | Stacy Ardoin MD | — |
| Completed | Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Re NCT02240888 | Region Skane | N/A |
| Completed | Vitamin D3 in Systemic Lupus Erythematosus NCT00710021 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Completed | QT Dispersion in Patients With Systemic Lupus Erythematosus (SLE) NCT01031797 | Shiraz University of Medical Sciences | — |
| Unknown | Efferocytosis and Genomic Polymorphism in Autoimmune Diseases NCT00364728 | National Taiwan University Hospital | — |
| Unknown | Role of DcR3 in T Cell Activation in SLE and RA NCT00275899 | National Taiwan University Hospital | — |
| Completed | Tacrolimus Versus Cyclophosphamide as Treatment for Lupus Nephritis NCT01207297 | Zhejiang University | Phase 1 |
| Terminated | Physical Therapy for Systemic Lupus Erythematosus (SLE) NCT00152555 | University of Chicago | N/A |