| Recruiting | The Experience of Screening for SCID NCT05651113 | King's College London | — |
| Completed | Feasibility Study to Assess an Adapted Physical Activity Program in Children, Adolescents and Young Adults Req NCT05298930 | Centre Leon Berard | N/A |
| Active Not Recruiting | Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for S NCT03597594 | St. Jude Children's Research Hospital | Phase 1 / Phase 2 |
| Unknown | Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiency NCT02860559 | Taiga Biotechnologies, Inc. | Phase 1 |
| Completed | Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograf NCT04246840 | Association Pour l'Aide a la Recherche en Immunologie Pediatrique | — |
| Withdrawn | A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoieti NCT04331483 | Centre Leon Berard | N/A |
| Completed | Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation NCT03513328 | University of Florida | Phase 1 / Phase 2 |
| Recruiting | Autologous Gene Therapy for Artemis-Deficient SCID NCT03538899 | University of California, San Francisco | Phase 1 / Phase 2 |
| Completed | Neonatal Screening of Severe Combined Immunodeficiencies NCT02590328 | Children's Hospital of Fudan University | — |
| Unknown | Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China NCT02231983 | Shanghai Children's Medical Center | — |
| Withdrawn | Sirolimus Prophylaxis for aGVHD in TME SCID NCT02177760 | University of California, San Francisco | Phase 2 |
| Completed | EZN-2279 in Patients With ADA-SCID NCT01420627 | Leadiant Biosciences, Inc. | Phase 3 |
| Active Not Recruiting | Immune Disorder HSCT Protocol NCT01821781 | Washington University School of Medicine | Phase 2 |
| Completed | Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem NCT01529827 | Roswell Park Cancer Institute | Phase 2 |
| Terminated | Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filg NCT01182675 | University of California, San Francisco | Phase 2 |
| Completed | Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammare NCT01129544 | David Williams | Phase 1 / Phase 2 |
| Completed | Newborn Screening for Severe Combined Immunodeficiency (SCID) in a High-Risk Population NCT00845416 | University of California, San Francisco | — |
| Completed | MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID NCT00794508 | Donald B. Kohn, M.D. | Phase 2 |
| Completed | Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked Products NCT00695279 | St. Jude Children's Research Hospital | — |
| Terminated | SCID Bu/Flu/ATG Study With T Cell Depletion NCT02127892 | Neena Kapoor, M.D. | Phase 1 / Phase 2 |
| Recruiting | Genetic Basis of Immunodeficiency NCT00055172 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome NCT00152100 | St. Jude Children's Research Hospital | Phase 1 |
| Completed | Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Dis NCT01019876 | Columbia University | Phase 2 / Phase 3 |
| Completed | Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients NCT00220766 | Grifols Therapeutics LLC | Phase 3 |
| Completed | Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID) NCT00028236 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 1 |
| Completed | Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID NCT00006335 | National Human Genome Research Institute (NHGRI) | — |
| Terminated | Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies NCT00006054 | Fairview University Medical Center | N/A |
| Completed | Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Com NCT00008450 | Fred Hutchinson Cancer Center | Phase 1 |
| Completed | Cord Blood Stem Cell Transplantation Study (COBLT) NCT00000603 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Defi NCT00001255 | National Human Genome Research Institute (NHGRI) | — |
| Completed | IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem C NCT00228852 | Emory University | Phase 1 / Phase 2 |
| Available | Expanded Access to CD34+ Selection Utilizing Miltenyi CliniMACS Prodigy® for Patients Receiving Peripheral Blo NCT06731036 | University of Florida | — |