| Not Yet Recruiting | Nanozymes in Endodontics NCT07518901 | University of Pennsylvania | Phase 4 |
| Recruiting | Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After R NCT07206108 | Nanfang Hospital, Southern Medical University | N/A |
| Active Not Recruiting | Toluidine Blue-Based Photodynamic Therapy for Antibacterial Activity and Postoperative Pain NCT07266233 | Ataturk University | N/A |
| Recruiting | Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial) NCT07048028 | ESRA DAĞCI | N/A |
| Active Not Recruiting | Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars NCT06811636 | Çanakkale Onsekiz Mart University | N/A |
| Completed | Comparative Analysis of Root Canal Microbiota in Diabetic and Systemically Healthy Patients NCT07047027 | Bulent Ecevit University | — |
| Not Yet Recruiting | Effectiveness of GentleWave System in Endodontic Treatment NCT06518304 | University of Salamanca | N/A |
| Completed | Comparison of Effectiveness of Disinfectants NCT06811779 | Armed Forces Institute of Dentistry, Pakistan | Phase 1 |
| Completed | Efficacy of Apical Preparation With Passive Ultrasonic Irrigation in Reducing Intracanal Bacteria NCT07005219 | Medipol University | N/A |
| Active Not Recruiting | Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal NCT06949176 | National and Kapodistrian University of Athens | N/A |
| Unknown | Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion NCT06035185 | Istanbul Medipol University Hospital | — |
| Terminated | Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection NCT05959629 | University of Pennsylvania | N/A |
| Enrolling By Invitation | Clinical Efficacy of AH Plus Bioceramic Sealer NCT05763420 | Ministry of Health, Kuwait | N/A |
| Enrolling By Invitation | Calcium Silicate Sealer-based Obturation in Root Canal Retreatment NCT05714384 | Ministry of Health, Kuwait | — |
| Unknown | Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide NCT05681221 | Cairo University | N/A |
| Completed | Comparison of Clinical Outcomes Between GentleWave® and Biolase® NCT05555043 | University of North Carolina, Chapel Hill | N/A |
| Unknown | Traditional Versus Conservative Access Cavities Cleaning Ability NCT06027931 | University of Baghdad | N/A |
| Completed | Effect of Cryotherapy and LLLT on Postoperative Pain After Root Canal Treatment NCT05476445 | Ataturk University | N/A |
| Completed | The Effects of EndoActivator on Postoperative Pain and Root Canal Treatment Success NCT06339905 | Istanbul Medipol University Hospital | N/A |
| Completed | Effect of EDDY Sonic Irrigation on Root Canal Microbiota and Pain in Asymptomatic Apical Periodontitis NCT07120126 | Abdulkadir Tiftik,DDS | N/A |
| Completed | Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. NCT05778227 | Dow University of Health Sciences | N/A |
| Completed | Clinical & Radiographic Evaluation of Zinc Oxide-Ozonated Oil as a New Primary Root Canal Filling NCT05633537 | Tanta University | N/A |
| Unknown | Evaluation of Post Operative Pain and Success Rate After Pulpotomy NCT04933955 | Ain Shams University | N/A |
| Unknown | Evaluation of Post Operative Pain Following Reciprocating and Rotary Heat-treated NiTi Instrumentation of Root NCT04655105 | Tamil Nadu Dr.M.G.R.Medical University | N/A |
| Completed | Success Rate of 4 Injection Protocols for Mandibular First Molars With Symptomatic Irreversible Pulpitis NCT04929522 | Ain Shams University | N/A |
| Completed | Radicular Dentin Remaining, Risk of Perforation and Canal Transportation in Manual Versus Rotary Instrumentati NCT04793308 | Cairo University | N/A |
| Completed | Releasing of Inflammatory Mediators During Retreatment of Root Canals NCT05039502 | Bulent Ecevit University | N/A |
| Completed | Bacterial Reduction and Post Operative Endodontic-pain Using Different Kinematics NCT04990115 | Ain Shams University | N/A |
| Completed | Ethanolic Extract of Sapindus Mukorrossi as Final Endodontic Irrigant. NCT05038059 | Dow University of Health Sciences | N/A |
| Unknown | Evaluation of Post Operative Pain in Retreatment of Molars Using Different Irrigant NCT04250519 | Tamil Nadu Dr.M.G.R.Medical University | Phase 1 |
| Unknown | Impact of an Enhanced Sterile Protocol on Root Canal Treatment Outcome NCT03636087 | King's College London | N/A |
| Withdrawn | Color Dental Alteration Caused by Endodontic Treatment NCT03841877 | Federal University of Pelotas | N/A |
| Completed | The Effect of Solvent Usage on Post-treatment Pain NCT03756363 | Yuzuncu Yil University | N/A |
| Recruiting | Outcome of Endodontic Retreatment in One or Two Visits NCT04527705 | Universitat Internacional de Catalunya | N/A |
| Completed | Occurrence of Post-op Pain Following Gentlewave NCT03635515 | University of Minnesota | N/A |
| Completed | One and Two-visit Root Canal Retreatment NCT05137613 | Ege University | N/A |
| Completed | Comparing Efficacy of a Stainless-steel Rotary File with Two Nickel-titanium Systems on Periapical Lesion Heal NCT06752837 | Beirut Arab University | N/A |
| Completed | Postoperative Pain After Root Canal Disinfection Via Diode Laser NCT03584880 | Yuzuncu Yil University | N/A |
| Completed | Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment NCT03990584 | Istanbul Medipol University Hospital | N/A |
| Unknown | Effect of Apical Negative Pressure Irrigation System at Cleaning Lateral Canals and Reduction of Periapical Le NCT03384004 | KaVo Kerr | N/A |
| Completed | Tooth Crown Discoloration Caused by Endodontic Treatment NCT03841370 | Federal University of Pelotas | — |
| Completed | 3D Analysis of Root Canal Conformation NCT03680534 | Institucion Universitaria Colegios de Colombia | N/A |
| Completed | Comparison of Antibacterial Efficacy of Three Final Irrigants NCT03853200 | Dow University of Health Sciences | Phase 2 / Phase 3 |
| Completed | Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques NCT03750162 | Bulent Ecevit University | N/A |
| Completed | Irrigants on Outcome of Non Surgical Endodontic Retreatment NCT03719404 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | One-visit Root Canal Treatment Using Chlorhexidine as a Final Irrigant NCT05006209 | Ege University | N/A |
| Completed | Postoperative Pain in Single-visit and Multiple-visit Retreatment Cases NCT03042377 | Istanbul Medipol University Hospital | Phase 4 |
| Completed | Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronida NCT03533231 | Tariq Yehia | Phase 4 |
| Completed | The Influences of Root Canal Complexity and Clinician Training on Root Canal Treatment Outcomes. NCT05648305 | Defence Primary Health Care, UK | — |
| Unknown | Prevalence of Bacteria Following Endodontic Treatment NCT03055975 | King's College London | — |
| Completed | Efficacy of Chlorhexidine as a Final Irrigant in Single-visit Root Canal Treatment NCT03336970 | Mehmet Kemal Çalışkan | N/A |
| Completed | Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy NCT04399720 | University of Bologna | — |