NCT05039502

Releasing of Inflammatory Mediators During Retreatment of Root Canals

The Effect of Different File Systems Used in Retreatment on the Release of Inflammatory Mediators

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Bulent Ecevit University · Academic / Other
• Sex: All
• Age: 18 Years – 68 Years
• Healthy volunteers: Accepted

Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Detailed description

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Conditions

• Inflammatory Response
• Root Canal Infection

Interventions

Type	Name	Description
OTHER	Protaper Universal Retreatment	D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor
OTHER	Reciproc	R25 retratment files were used with X-Smart endomotor in reciprocal motion
OTHER	XP-Endo finisher R	XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Timeline

• Start date: 2020-10-01
• Primary completion: 2021-03-15
• Completion: 2021-06-01
• First posted: 2021-09-09
• Last updated: 2021-09-09

Locations

1 site across 1 country: Turkey (Türkiye)