NCT07206108

Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment

A Multicenter, Randomized Controlled, Single-blind, Non-inferiority Clinical Trial of Modified Endocrown and Personalized Post Core Combined With Full Crown for Large-area Tooth Defects After Root Canal Treatment

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 246 (estimated)
• Sponsor: Nanfang Hospital, Southern Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study intends to adopt a multicenter, randomized controlled, single-blind, non-inferiority clinical trial design. 246 premolars that meet the inclusion criteria after complete root canal treatment will be selected from the clinical practice and randomly divided into two groups. One group will be restored with the modified endocrown, and the other group will be restored with personalized post and core combined with full crown. Follow-up visits were conducted at 6 months, 1 year and 2 years after the operation respectively. Through clinical and imaging examinations, the survival rates of the two different restorations were evaluated and used as the main evaluation indicators to fill the gap in efficacy data of the modified endocrown in clinical applications, providing a strong evidence-based medical basis for subsequent restoration improvement and standardized application.

Conditions

• Root Canal Infection
• Tooth Defect
• Post and Core Technique

Interventions

Type	Name	Description
PROCEDURE	modified endocrown	Combining the advantages of post-core crown and endocrown, an modified endocrown was designed

Timeline

• Start date: 2025-08-04
• Primary completion: 2029-12-31
• Completion: 2029-12-31
• First posted: 2025-10-03
• Last updated: 2025-10-03

Locations

1 site across 1 country: China