| Recruiting | Clinical-ultrasonographic Assessment of Pulmonary Emphysema NCT06533371 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Video Assisted Thoracic Surgery (VATS) Fissure Completion Prior to Zephyr® Endobronchial Valve Insertion NCT04465461 | Pulmonx Corporation | N/A |
| Completed | Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV NCT04161235 | Pulmonx Corporation | — |
| Completed | Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax NCT04012359 | University Hospital, Rouen | — |
| Unknown | Allogeneic MSC Treatment for Pulmonary Emphysema NCT04918706 | Leiden University Medical Center | Phase 2 |
| Unknown | Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils NCT02879331 | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | N/A |
| Completed | Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic NCT02719184 | Boehringer Ingelheim | — |
| Unknown | Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD) NCT02827721 | Universitätsmedizin Mannheim | — |
| Unknown | Diagnostic Value of Ultralow-dose Computed Tomography for the Detection of Pulmonary Nodules and Lung Parenchy NCT02468609 | Cantonal Hospital of St. Gallen | N/A |
| Completed | Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema NCT02382367 | Hospices Civils de Lyon | N/A |
| Terminated | In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients NCT02556697 | University Hospital, Rouen | N/A |
| Withdrawn | Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone NCT01849159 | Federal Research Clinical Center of Federal Medical & Biological Agency, Russia | Phase 1 / Phase 2 |
| Terminated | Post-hospitalisation Nutritional Support and Gait Speed in COPD NCT02261350 | Royal Brompton & Harefield NHS Foundation Trust | Phase 3 |
| Completed | Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysem NCT01872624 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Low Cost Biological Lung Volume Reduction Therapy for Advanced Emphysema NCT02107209 | Mansoura University | Phase 2 |
| Completed | The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Pat NCT01869205 | Asan Medical Center | Phase 3 |
| Terminated | Long Term Follow up Investigation of Endobronchial Valves in Emphysema NCT01580215 | Pulmonx International Sàrl | — |
| Terminated | Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE) NCT01449292 | Aeris Therapeutics | Phase 3 |
| Terminated | Collateral Ventilation Effects on Response to AeriSeal System Treatment in Upper Lobe Predominant Emphysema NCT01520740 | Aeris Therapeutics | Phase 4 |
| Terminated | Post Market Registry Study of the AeriSeal System NCT01520064 | Aeris Therapeutics | — |
| Completed | eRT Remote Health Monitoring NCT01495780 | University of California, Los Angeles | N/A |
| Completed | Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbatio NCT01507415 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Completed | Implantation of Endobronchial Valves Versus Intrabronchial Valves in Patients With Severe Heterogeneous Emphys NCT01457833 | Heidelberg University | N/A |
| Unknown | AeriSeal System in Patients With Advanced Upper Lobe Predominant Emphysema and Collateral Ventilation NCT01460108 | LudwLudwig Boltzmann Institute for COPD and Respiratory Epidemiology | Phase 4 |
| Completed | Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease NCT01515709 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Terminated | A Continuation Study of the AeriSeal® System Administered at 3 to 4 Sites During a Single Treatment Session fo NCT01320566 | Aeris Therapeutics | Phase 2 / Phase 3 |
| Completed | AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema NCT01181466 | Aeris Therapeutics | Phase 2 / Phase 3 |
| Completed | ELVR in PH Patients With Severe Emphysema NCT01393379 | Heidelberg University | — |
| Completed | AeriSeal System for Lung Volume Reduction NCT01051258 | Aeris Therapeutics | Phase 1 / Phase 2 |
| Unknown | Unilateral Versus Bilateral Endoscopic Lung Volume Reduction A Comparative Case Study NCT00995852 | Heidelberg University | Phase 2 / Phase 3 |
| Completed | A Phase I Study of iPS Cell Generation From Patients With COPD NCT01860898 | Mayo Clinic | N/A |
| Completed | Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease NCT01110252 | UPECLIN HC FM Botucatu Unesp | N/A |
| Unknown | Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD) NCT00857038 | Medical Center Alkmaar | Phase 4 |
| Completed | PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Dise NCT00683722 | Mesoblast, Inc. | Phase 2 |
| Completed | Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Pa NCT00680056 | Federal University of São Paulo | Phase 4 |
| Completed | US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study NCT00515164 | Aeris Therapeutics | Phase 2 |
| Completed | Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study NCT00517998 | Aeris Therapeutics | Phase 1 |
| Completed | US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study NCT00435253 | Aeris Therapeutics | Phase 2 |
| Completed | US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study NCT00347659 | Aeris Therapeutics | Phase 1 |
| Completed | Innovation in Pulmonary Rehabilitation NCT00123422 | US Department of Veterans Affairs | N/A |
| Terminated | Netherlands 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation NCT00205920 | Aeris Therapeutics | Phase 2 |
| Completed | US 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study - Initial Formulation NCT00085852 | Aeris Therapeutics | Phase 1 |
| Terminated | Israeli 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1/2 Emphysema Study - Initial Formulation NCT00205907 | Aeris Therapeutics | Phase 1 / Phase 2 |
| Completed | Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) NCT00051792 | National Center for Complementary and Integrative Health (NCCIH) | Phase 1 / Phase 2 |
| Completed | Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery NCT00566839 | University of Rome Tor Vergata | Phase 2 |