| Not Yet Recruiting | VR-PAT and fNIRS to Identify CNS Biomarkers of Pain NCT06303687 | Nationwide Children's Hospital | N/A |
| Active Not Recruiting | Effect of Bagua Auriculotherapy on Pain in Patients Undergoing Hysteroscopy NCT07512791 | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | N/A |
| Not Yet Recruiting | Intravenous Nalbuphine Versus Lidocaine for Prevention of Propofol Injection Pain NCT07422558 | Hayatabad Medical Complex | N/A |
| Not Yet Recruiting | Palm Stimulator Use During Peripheral Venous Catheterization NCT07387497 | Zeliha CENGİZ | N/A |
| Not Yet Recruiting | The Effect of Two Different Types of Hourglasses on Pain, Fear, and Anxiety NCT07312084 | Hakkari Universitesi | N/A |
| Not Yet Recruiting | Effects of Rain Stick and Musical Egg on Pain, Fear and Anxiety NCT06983093 | Hakkari Universitesi | N/A |
| Recruiting | Oral Surgery Virtual Reality Glasses Study NCT06723158 | Boston University | N/A |
| Completed | Effects of Liquid Hourglass and Spiky Ball on Pain, Fear, Anxiety and Emotional Manifestations NCT06994637 | Hakkari Universitesi | N/A |
| Completed | Effectiveness of Gentle Touch Technique on Pain Level During Painful Procedures in Preterm Infants NCT07470398 | Karbala University | N/A |
| Recruiting | Virtual Reality for Pain Control in US-Guided Obstetric Needle Procedures NCT07094451 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | Cervical Preparation for Same-Day Dilation & Evacuation NCT06799052 | Boston Medical Center | N/A |
| Enrolling By Invitation | The Effect of Two Different Interventions on Emotional State, Pain, and Fear During Respiratory Panel Removal NCT07319806 | Sakarya University | N/A |
| Recruiting | Virtual Reality Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care NCT06913270 | Al Hayah University In Cairo | N/A |
| Completed | Kaleidoscope and Helicone for Pain and Anxiety in Children NCT07068672 | AYLİN ARIKAN | N/A |
| Not Yet Recruiting | To Explore the Optimal Dose of Dexmedetomidine for Skull Pin Fixation in Intracranial Surgery NCT06837818 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Phase 4 |
| Recruiting | Trauma-Informed Procedural Pain Intervention: Refinement of an Evidence-Based Protocol NCT06705491 | University of Louisville | N/A |
| Recruiting | TEAS for Sedation During ERCP: A Multicenter Trial NCT07440342 | Beijing 302 Hospital | N/A |
| Recruiting | Comparison of Compounded Topical Anesthetics NCT06569537 | Dartmouth-Hitchcock Medical Center | Phase 4 |
| Not Yet Recruiting | Pain Elimination and Anxiety Control Through Experiential Virtual Reality NCT06504602 | Children's Hospital Los Angeles | N/A |
| Completed | Two Different Distraction Methods for Reducing Procedural Pain in Children NCT06541964 | Maltepe University | N/A |
| Not Yet Recruiting | To Explore the Optimal Dose of Alfentanil for Skull Pin Fixation in Intracranial Surgery NCT06563297 | Kaohsiung Medical University Chung-Ho Memorial Hospital | Phase 4 |
| Completed | Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement NCT06590870 | Mount Sinai Hospital, Canada | Phase 3 |
| Completed | The Effect of Mechanical Vibration and Helfer Skin Tap Technique on Procedural Pain in Infants During Vaccinat NCT06454812 | Istanbul Medeniyet University | N/A |
| Completed | The Effect of Facilitated-tucking and ShotBlocker on Pain Caused by Vaccination in Healthy Infants NCT06377748 | Istanbul Medeniyet University | N/A |
| Active Not Recruiting | VR Augmented Human Delivered Integrative Psychotherapy for Colonoscopy Procedural Anxiety and Pain NCT06346171 | Grigore T. Popa University of Medicine and Pharmacy | N/A |
| Not Yet Recruiting | Procedural Pain Management by Multimodal Sedation Analgesia Combining Hypnosis in Children With Congenital Hea NCT06373627 | Fondation Hôpital Saint-Joseph | N/A |
| Completed | The Effect of Watching Cartoons and Playing Games as Distraction Method During Peripheral Intravenous Cannula NCT06371599 | Mersin University | N/A |
| Completed | Effects of Squeezing Ball and Using Adhesive Remover on Pain and Fear in Children Aged 6-9 Years During the Re NCT06371612 | Mersin University | N/A |
| Recruiting | Intranasal Versus Intravenous Fentanyl For Procedural Analgesia in Preterm Neonates NCT07190625 | Ain Shams University | EARLY_Phase 1 |
| Recruiting | The Effect of Audio Book and Local Vibration on Pain and Fear in Intramuscular Injection in Children NCT06354608 | University of Yalova | N/A |
| Unknown | Effect of TENS Application After Thoracic Surgery NCT05927168 | Cukurova University | N/A |
| Recruiting | Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy NCT05895383 | Beth Israel Deaconess Medical Center | Phase 4 |
| Unknown | Neonatal Pain Management and Pain Monitoring Using New Methods NCT04967118 | University of Oulu | N/A |
| Completed | Virtual Reality Outperforms Game Card Distraction in Reducing Distress During Pediatric Wound Care NCT07335666 | Agri Ibrahim Cecen University | N/A |
| Enrolling By Invitation | VR-PAT During Home Burn Dressings - Multisite NCT05673551 | Nationwide Children's Hospital | N/A |
| Active Not Recruiting | VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser Procedures NCT05645224 | Nationwide Children's Hospital | N/A |
| Completed | The Effect of Mechanical Vibration and ShotBlocker on Pain Levels During Heel Lance in Healthy Term Neonates NCT06380556 | Istanbul Medeniyet University | N/A |
| Unknown | Virtual Reality for Anxiety and Pain Management During Oocyte Retrieval in IVF/ICSI Treatment NCT05555498 | Amsterdam UMC, location VUmc | N/A |
| Recruiting | Impact of Virtual Reality in Hematology and Oncology During Invasive Procedures in Children, Adolescents and Y NCT05275881 | Poitiers University Hospital | N/A |
| Completed | The Effect of Music Therapy and Breathing Exercise on Anxiety and Pain in Patients Undergoing Coronary Angiogr NCT06264960 | Ulku Gunes | N/A |
| Completed | Leap Motion Controller for Pain During Venipuncture in Pediatrics NCT05441241 | IRCCS Burlo Garofolo | N/A |
| Completed | Remimazolam Sedation for Nerve Blocks NCT05415202 | University of Utah | — |
| Completed | Pain and Fear During Intravenous Blood Collection in Children NCT06044701 | Ege University | N/A |
| Completed | Do Vacutainers With Animal Characters Reduce Fear and Anxiety? NCT06345911 | Burdur Mehmet Akif Ersoy University | N/A |
| Completed | Effect of Acupressure on Interventional Pain in Infants NCT05166551 | Istanbul University - Cerrahpasa | N/A |
| Completed | Efficacy of Finger Puppet as a Distraction Method NCT05073497 | Biruni University | N/A |
| Unknown | Nebulized Lidocaine and Intranasal Midazolam for NGT Insertion in Children NCT04571879 | Hamad Medical Corporation | Phase 3 |
| Completed | The Effect of Pain Management Education on The Mothers in Newborn NCT05173662 | Selcuk University | N/A |
| Completed | Impact of Virtual Reality on Peri-interventional Pain, Anxiety and Distress in a Pediatric Oncology Outpatient NCT06235723 | Hannover Medical School | N/A |
| Completed | The Effect of Dry Heat and Dry Cold Application on Blood Sampling in Children NCT05974319 | Saglik Bilimleri Universitesi | N/A |
| Unknown | Intranasal Versus Intravenous Drug in Painful Procedure for Outpatient Oncologic Participants NCT04621110 | University of Sao Paulo General Hospital | Phase 3 |
| Completed | Maternal Involvement in Pain Management in NICU NCT04883944 | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | N/A |
| Completed | Comparing Buzzy Device With Emla Cream in Needle Related Pain NCT05354739 | Hamad Medical Corporation | — |
| Completed | Non-immersive Virtual Reality for Pediatric Pain Management NCT03985930 | Claudia Aristizábal | N/A |
| Unknown | Distal Radial Access for Coronary Procedures NCT06165406 | Hospital Arnau de Vilanova | — |
| Unknown | Pharmacogenetics of Ketamine in Children NCT05796232 | IRCCS Burlo Garofolo | — |
| Completed | Can Virtual Reality Reduce Pain and Anxiety During Blood Draw NCT04449341 | C.R.Darnall Army Medical Center | N/A |
| Completed | Addition of Buprenorphine to Paracervical Block for Pain Control During Osmotic Dilator Insertion NCT04254081 | University of California, San Diego | Phase 4 |
| Completed | Crochet Octopus in The Process of Heel Lance in Neonates NCT04560374 | Marmara University | N/A |
| Completed | Parental Involvement in Pain Reducing Measures NCT05656677 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Pain, Anxiety During Interventional Spine Procedures NCT04257019 | MetroHealth Medical Center | N/A |
| Completed | VR for Burn Dressing Changes at Home NCT04548635 | Nationwide Children's Hospital | Phase 2 / Phase 3 |
| Unknown | Multimodal Approach to the Ontogenesis of Nociception in Very Preterm and Term Infants NCT05404594 | University Hospital, Strasbourg, France | N/A |
| Unknown | Effects of Virtual Reality, External Cold and Vibration to Children During IM Injection on Pain, Fear and Anxi NCT05434832 | Akdeniz University | N/A |
| Unknown | Effects of Virtual Reality, Cold-Vibration Due To Intravenous Catheterization on Pain, Fear and Anxiety on Chi NCT05435105 | Akdeniz University | N/A |
| Unknown | Effect of Virtual Reality Distraction on Procedural Pain for Children and Adolescents in Onco-Hematology Unit. NCT03888690 | Central Hospital, Nancy, France | N/A |
| Unknown | Virtual Reality for Alleviation of Peripheral IV Placement-Associated Discomfort NCT03740607 | Brooke Army Medical Center | N/A |
| Completed | Breathing Toy for Pain Relief in Pediatric Venipuncture NCT07430514 | Koç University | N/A |
| Completed | Parent Targeted Interventions in Vaccination Pain Management of Infants NCT03968432 | University of Ottawa | N/A |
| Completed | The Effect of Cognitive-Behavioral Intervention Package on Procedural Pain and Anxiety in Children NCT06018909 | Aynur Aytekin Ozdemir | N/A |
| Completed | Auditory Intraoperative Stimulation Effects on Pain and Agitation at Awakening (AUDIOPAW) NCT04112979 | IRCCS Burlo Garofolo | N/A |
| Completed | Nonpharmacological Methods for Children in Procedural Pain NCT04421430 | Istanbul Medeniyet University | N/A |
| Completed | Nonpharmacological Methods for Children NCT05070325 | Bandırma Onyedi Eylül University | N/A |
| Completed | Efficacy of VR and Buzzy on Pain and Anxiety NCT05179291 | Bandırma Onyedi Eylül University | N/A |
| Completed | Analgesic Effect of Low Level Laser for Procedural Pain in Newborn Infants NCT03268148 | Chang Gung Memorial Hospital | N/A |
| Completed | Effect of Guided Imagery Method on Procedural Pain in Children NCT04978532 | Biruni University | N/A |
| Completed | Paternal vs Maternal Holding-Cuddling for Procedural Pain in Healthy Term Neonates NCT06111534 | Istanbul Medeniyet University | N/A |
| Completed | The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety NCT06310850 | Ankara Ataturk Sanatorium Training and Research Hospital | Phase 3 |
| Completed | A Test of the Effectiveness of a Device and Distraction for Pediatric Immunization Pain NCT01152489 | MMJ Labs LLC | Phase 2 / Phase 3 |
| Unknown | Analgesic Effect of Breastmilk for Procedural Pain in Preterm Infants NCT00908401 | Centre Hospitalier Intercommunal Creteil | Phase 3 |
| Completed | Analgesic Properties of Oral Sucrose During Immunizations NCT00446875 | Milton S. Hershey Medical Center | N/A |
| Completed | Skin Blood Flow Changes Using Laser Doppler Imager for Assessment of Pain and Analgesia in Newborn Infants NCT00694174 | Children's Hospital of Michigan | Phase 4 |
| Completed | Efficacy and Safety of ALGRX 3268 in Management of Needlestick Pain in Children. NCT00140088 | AlgoRx Pharmaceuticals | Phase 3 |
| Completed | Utilization of Oral Sucrose to Decrease Pain in Infants During Immunizations NCT00150189 | Milton S. Hershey Medical Center | N/A |