| Not Yet Recruiting | Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA NCT07380490 | Giuseppe Tarantini | N/A |
| Recruiting | Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine NCT07170176 | First Affiliated Hospital Xi'an Jiaotong University | N/A |
| Recruiting | Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: T NCT07172464 | Recross Cardio, Inc. | N/A |
| Not Yet Recruiting | Pioneering Advancements in Cardiocerebrovascular Interactions in the Asia pacFIC - Patent Foramen Ovale Study NCT06983795 | National University Hospital, Singapore | — |
| Withdrawn | Close Obstructive Sleep Apnea (OSA) Trial NCT06113562 | University of Miami | N/A |
| Recruiting | Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure NCT05907694 | Josep Rodes-Cabau | N/A |
| Not Yet Recruiting | Long-term Procedural and Device Related Complications of PFO Closure NCT06413147 | Xuanwu Hospital, Beijing | — |
| Not Yet Recruiting | Cardiac Interventional ICE Imaging Trial NCT06344494 | ICE Intelligent Healthcare Co., Ltd | N/A |
| Not Yet Recruiting | AWARE Registry: Wearable ECG in Structural Heart Interventions NCT06236776 | Yonsei University | — |
| Recruiting | Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale NCT06953622 | Peking University Third Hospital | — |
| Recruiting | Russian Registry of Endovascular Closure of PFO NCT06156670 | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | — |
| Recruiting | CeraFlex PFO Closure System PMCF Study NCT06120270 | Lifetech Scientific (Shenzhen) Co., Ltd. | — |
| Not Yet Recruiting | Study on the Safety and Effectiveness of the SnowyTM PFO Closure System NCT05360771 | Hangzhou Dinova EP Technology Co., Ltd | N/A |
| Completed | Lifetech Cera™ PFO Occluder Post-Market Clinical Follow-Up NCT05893758 | Lifetech Scientific (Shenzhen) Co., Ltd. | — |
| Recruiting | Encore PFO Closure Device - The PerFOrm Trial NCT05537753 | Encore Medical Inc. | N/A |
| Recruiting | PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 NCT05387954 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Unknown | Patent Foramen Ovale (PFO) and Risk of Perioperative Stroke NCT05592301 | University Health Network, Toronto | — |
| Recruiting | Safety and Efficacy of Cera™ Patent Foramen Ovale Occluders. NCT05774288 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Completed | Comparison of Lower vs Upper Extremity Injection Agitated Saline to Identify Patent Foramen Ovale With Echocar NCT07009678 | St. John's Hospital | N/A |
| Unknown | Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale NCT05546320 | Chinese Academy of Medical Sciences, Fuwai Hospital | Phase 4 |
| Unknown | COMParison of the EffecT of dEvice Closure in Alleviating Migraine With PFO (COMPETE-2) NCT05561660 | Chinese Academy of Medical Sciences, Fuwai Hospital | Phase 4 |
| Unknown | Assessment of Early Vascular Damage With Advanced Neuroimaging in Patient With Patent Foramen Ovale NCT04549272 | Neuromed IRCCS | — |
| Completed | Patent Foramen Ovale Closure in Migraine NCT06192173 | Haiyan Wang | — |
| Active Not Recruiting | Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion NCT05069558 | Occlutech International AB | N/A |
| Withdrawn | Safety and Efficacy of IrisFIT™ Patent Foramen Ovale Occluders NCT05312554 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Active Not Recruiting | Assessment of Flecainide to Lower the Patent Foramen Ovale Closure Risk of Atrial Arrhythmia or Tachycardia NCT05213104 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Philips Intracardiac Echocardiography (ICE) Clinical Registry NCT04950192 | Philips Clinical & Medical Affairs Global | — |
| Unknown | Prevalence of Atrial Fibrillation in Cryptogenic Stroke With Patent Foramen Ovale Closure (PFO-AF) Study NCT04926142 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Patent Foramen Ovale Closure in Older Patients NCT04780022 | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | — |
| Terminated | GORE® CARDIOFORM Septal Occluder Migraine Clinical Study NCT04100135 | W.L.Gore & Associates | N/A |
| Recruiting | Internal Microstructure of Patent Foramen Ovale Related to Stroke NCT04686253 | China National Center for Cardiovascular Diseases | — |
| Completed | RoBotic TCD Ultrasound BubbLe Study Compared to Transthoracic Echocardiography for Detection of Right to Left NCT04604015 | NovaSignal Corp. | N/A |
| Unknown | Evaluation of the Severity of Right to Left Shunt in PFO Patients After Systemic Embolism NCT04610463 | University Hospital Hradec Kralove | N/A |
| Recruiting | Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryp NCT04475510 | Josep Rodes-Cabau | N/A |
| Not Yet Recruiting | Canadian Adult Congenital Heart Disease Intervention Registry NCT04288596 | University Health Network, Toronto | — |
| Unknown | Post Market Registry of the CBSO NCT04105595 | atHeart Medical | — |
| Unknown | PFO Occlusion and Atrial Fibrillation NCT04898361 | University Hospital, Saarland | N/A |
| Unknown | International Multicenter Patent foRamen OVale & strokE (IMPROVE) Registry NCT04738071 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Completed | Is Blood Flow Through IPAVA and PFO Related to Breath-hold and SCUBA Diving-induced Pulmonary Hypertension? NCT03945643 | University of Oregon | EARLY_Phase 1 |
| Active Not Recruiting | Evaluation of the Efficacy and Safety of a Simplified Procedure for the Percutaneous Closure of the Patent For NCT03828825 | Fondation Hôpital Saint-Joseph | N/A |
| Completed | Does Patent Foramen Ovale Size Matter in Men and Women NCT03904277 | University of Oregon | — |
| Unknown | Does Patent Foramen Ovale Closure Improve Exercise Capacity & Prevent Blood Flow Through Intrapulmonary Shunt NCT03904290 | University of Oregon | N/A |
| Completed | pLatelEts And MigRaine iN patEnt foRamen Ovale NCT03521193 | Centro Cardiologico Monzino | N/A |
| Active Not Recruiting | AMPLATZER PFO Occluder Post Approval Study NCT03309332 | Abbott Medical Devices | N/A |
| Unknown | Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches NCT02777359 | First Affiliated Hospital Xi'an Jiaotong University | Phase 2 |
| Completed | Patent Foramen Ovale Closure Reduce in SCUBA-divers NCT03997084 | Skane University Hospital | — |
| Completed | Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course NCT03377465 | Medical University of Lodz | N/A |
| Completed | Anticoagulants for PFO Patients NCT06375070 | Xuanwu Hospital, Beijing | — |
| Completed | Lifetech CeraFlex™ Post-Market Surveillance Study NCT02621528 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Withdrawn | Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Embo NCT02378623 | Mayo Clinic | Phase 2 |
| Unknown | Influence of Position on Detection of Patent Foramen Ovale by Simultaneous Transesophageal Echo and Transcrani NCT02383836 | Hillel Yaffe Medical Center | — |
| Completed | Post Market Clinical Follow-up Study of IrisFITTM PFO (Patent Foramen Ovale) Occluder NCT02882815 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Completed | Residual Shunt After Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke NCT03416426 | Gachon University Gil Medical Center | — |
| Completed | Nitrogen Bubble Detection After Simulated Dives in Divers With PFO and After PFO Closure NCT01854281 | University Hospital, Motol | — |
| Unknown | PFO Closure for Obstructive Sleep Apnoea NCT02771561 | Papworth Hospital NHS Foundation Trust | N/A |
| Terminated | Right to Left Cardiac Shunt Detection NCT01773252 | Cardiox Corporation | Phase 3 |
| Unknown | Device Closure Versus Medical Therapy for Cryptogenic Stroke Patients With High-Risk Patent Foramen Ovale (DEF NCT01550588 | Jae-Kwan Song | Phase 4 |
| Terminated | Cardiox Shunt Detection Technology Study NCT01333761 | Cardiox Corporation | Phase 3 |
| Terminated | Nickel Allergy With Septal Closure Devices NCT01068366 | University of Utah | — |
| Completed | Comorbidities Associated With Migraine and Patent Foramen Ovale (CAMP) NCT01257880 | Swedish Medical Center | — |
| Completed | Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale NCT01216423 | University Hospital, Brest | — |
| Terminated | The Effect of Device Closure of Patent Foramen Ovale in Elderly Patients With Crytogenic Stoke/TCI NCT01018355 | Hillerod Hospital, Denmark | N/A |
| Completed | Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence NCT00562289 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | Risk of Stroke in Pulmonary Embolism With a Patent Foramen Ovale (PFO) NCT00831259 | University Hospital, Caen | — |
| Terminated | PRIMA PFO Migraine Trial NCT00505570 | Abbott Medical Devices | Phase 2 |
| Suspended | PFx Closure System in Subjects With Cryptogenic Stroke,Transient Ischemic Attack,Migraine or Decompression Ill NCT00335296 | Cierra | N/A |
| Unknown | MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant NCT00283738 | NMT Medical | Phase 2 / Phase 3 |
| Completed | PREMIUM Migraine Trial NCT00355056 | Abbott Medical Devices | N/A |
| Unknown | Paradigm I Clinical Trial: Study of the PFX Closure System in Subjects With Cryptogenic Stroke, Transient Isch NCT00196027 | Cierra | N/A |
| Unknown | Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage NCT00201461 | NMT Medical | Phase 2 / Phase 3 |
| Completed | PFO tRanscatether Occlusion Long-term Outcomes National Group (PROLONG) Registry NCT06504121 | IRCCS Ospedale San Raffaele | — |
| Completed | Patent Foramen Ovale in Cryptogenic Stroke Study NCT00697151 | Columbia University | Phase 4 |
| Completed | Safety and Effectiveness Study of the Solysafe Septal Occluder in Patients With Atrial Septum Defect and Paten NCT00207376 | Carag AG | N/A |
| Approved For Marketing | Emergency/Compassionate Use PFO Occluder NCT00584064 | Abbott Medical Devices | — |
| No Longer Available | PFO ACCESS Registry NCT00583401 | Abbott Medical Devices | — |