| Recruiting | PDA for Kidneys Study NCT06658496 | University of Wisconsin, Madison | — |
| Recruiting | NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot NCT06646250 | St. Olavs Hospital | — |
| Recruiting | Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT NCT07143201 | Hamilton Health Sciences Corporation | Phase 2 |
| Completed | The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease NCT06298344 | Universitas Sumatera Utara | EARLY_Phase 1 |
| Unknown | Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arter NCT06256211 | Soha mahmoud Hussien mahdy | Phase 1 / Phase 2 |
| Unknown | Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus NCT06152796 | Assiut University | Phase 2 |
| Not Yet Recruiting | PUFAs in Preterm Infants NCT06045130 | The First Hospital of Jilin University | — |
| Completed | Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus NCT05639309 | Seoul St. Mary's Hospital | — |
| Recruiting | Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patie NCT05264753 | Occlutech International AB | — |
| Unknown | PAIR (Paracetamol and Ibuprofen Research) Pilot Trial NCT04986839 | Manchester University NHS Foundation Trust | Phase 2 / Phase 3 |
| Unknown | Optimal Dose of Surfactant for Preterm Infants With Respiratory Distress Syndrome NCT04984057 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | N/A |
| Unknown | Aminoglycosides and Duct NCT04415554 | Carmel Medical Center | — |
| Unknown | Effect of PDA Closure on the Left Ventricular Remodeling NCT04964531 | Ahmed Mohamed Moheb El-Din | — |
| Withdrawn | Addition of Acetaminophen in Standard PDA Management NCT04026464 | University of Florida | Phase 2 |
| Unknown | Clinical Profile of Neonates Having Patent Ductus Arteriosus NCT04672629 | Assiut University | — |
| Terminated | Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants NCT03982342 | Nationwide Children's Hospital | N/A |
| Completed | Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort NCT07533721 | Shengjing Hospital | — |
| Unknown | Population Pharmacokinetics and Dosage Individualization of Paracetamol and Ibuprofen in Children With PDA NCT04397913 | Shandong University | — |
| Active Not Recruiting | Amplatzer Piccolo Occluder Japan Post-marketing Database Surveillance NCT04371081 | Abbott Medical Devices | — |
| Enrolling By Invitation | Improving Care for Children With Congenital Heart Disease. NCT04667455 | Lund University Hospital | N/A |
| Completed | Canadian National PDA Treatment Study NCT04347720 | IWK Health Centre | — |
| Completed | Timing of Surgical PDA Ligation and Neonatal Outcomes NCT04126512 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Active Not Recruiting | Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes NCT03782610 | Nationwide Children's Hospital | — |
| Active Not Recruiting | Management of the PDA Trial NCT03456336 | NICHD Neonatal Research Network | Phase 3 |
| Completed | Early Treatment Versus Expectant Management of PDA in Preterm Infants NCT03860428 | Lviv National Medical University | N/A |
| Unknown | A NEW SCORING SYSTEM FOR PREDICTION OF PDA NCT04270240 | Kanuni Sultan Suleyman Training and Research Hospital | — |
| Terminated | Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Co NCT03701074 | University of South Alabama | Phase 2 |
| Unknown | Feasibility, Efficacy and Safety of IBS ® for Implantaiton in the PDA in Duct-dependent Cyanotic CHD NCT04291222 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Terminated | Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus NCT03648437 | University of Oulu | Phase 1 |
| Completed | Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants NCT04184245 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Cardio-respiratory Events in Preterm Infants During Transition NCT04123691 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Treatment of a PDA With Acetaminophen in Preterm Neonates: Exploring Various Indications NCT03289390 | Albany Medical College | — |
| Completed | MISA to NRDS：a Multicenter Study in China NCT04077333 | Peking University Third Hospital | N/A |
| Completed | Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus NCT03103022 | University of Florida | Phase 1 |
| Completed | AMPLATZER Duct Occluder II Additional Sizes NCT03055858 | Abbott Medical Devices | N/A |
| Unknown | International Experience in Timing And Choices for Ductal Closure in Patent Ductus Arteriosus:INTERPDA Trial NCT02910609 | Ankara University | — |
| Completed | IV Acetaminophen and Patent Ductus Arteriosus NCT03008876 | Albany Medical College | N/A |
| Completed | Early Treatment Versus Expectative Management of PDA in Preterm Infants NCT02884219 | Radboud University Medical Center | N/A |
| Terminated | Near Infrared Spectroscopy to Determine Patent Ductus Arteriosus Closure NCT03026192 | Albany Medical College | — |
| Unknown | A New Device for Measuring of Lung Photoplethysmography and Pulmonic Arterial Saturation NCT02894970 | Shaare Zedek Medical Center | — |
| Terminated | Acetaminophen vs Indomethacin in Treating hsPDA NCT03537144 | University of Tennessee | Phase 3 |
| Unknown | Paracetamol Treatment of the Borderline Significant PDA NCT02819414 | Shaare Zedek Medical Center | Phase 2 |
| Completed | PDA Post NICU Discharge NCT02750228 | Pediatrix | — |
| Completed | Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates NCT03022253 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 3 |
| Completed | Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus NCT03551600 | University of Utah | — |
| Completed | Lifetech CeraFlex™ Post-Market Surveillance Study NCT02621528 | Lifetech Scientific (Shenzhen) Co., Ltd. | N/A |
| Unknown | Paracetamol Versus Ibuprofen for PDA Closure NCT03265782 | Ain Shams University | Phase 4 |
| Completed | Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus. NCT03277768 | University of Florida | — |
| Unknown | Hyperion™ International Registry Trial NCT02220270 | European Cardiovascular Research Center | — |
| Unknown | Radiation-Free Heart Catheterization Using MRI NCT02739087 | Joshua Kanter | N/A |
| Unknown | Plethismographic Perfusion Index in Neonates NCT02380040 | Shaare Zedek Medical Center | — |
| Completed | Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus NCT01958320 | University of California, San Francisco | Phase 2 |
| Completed | Patent Ductus Arteriosus and Splanchnic Oxygenation at First Feed NCT03723889 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Pocket Echocardiography System (PES) for Detection of PDA in Neonates NCT01790750 | University of Florida | N/A |
| Unknown | Paracetamol and Patent Ductus Arteriosus (PDA) NCT01291654 | Shaare Zedek Medical Center | Phase 2 |
| Completed | Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI) NCT01630278 | Nantes University Hospital | Phase 3 |
| Unknown | Serum Level Measurement of Oral Paracetamol and Oral Ibuprofen for Patent Ductus Arteriosus Treatment in Prete NCT01544972 | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 4 |
| Completed | Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomi NCT01536158 | Zekai Tahir Burak Women's Health Research and Education Hospital | Phase 4 |
| Completed | Do Elevated BNP Levels Predict Hemodynamically Significant PDAs NCT01497054 | Albany Medical College | — |
| Completed | Safety and Effectiveness Study With a New PDA Occluder for Closure of Patent Ductus Arteriosus NCT01479218 | Occlutech International AB | N/A |
| Completed | Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants NCT01428180 | University of Ulm | — |
| Completed | Safety and Efficacy of Ibuprofen in Term Newborns With Patent Ductus Arteriosus (PDA) NCT01511887 | Hormozgan University of Medical Sciences | N/A |
| Withdrawn | Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability NCT01028183 | Duke University | — |
| Withdrawn | Second Course of Therapy for Resistant Patent Ductus Arteriosus (PDA) NCT01070745 | Shaare Zedek Medical Center | Phase 2 |
| Terminated | Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates NCT00961753 | OSF Healthcare System | Phase 4 |
| Completed | Echocardiographically Guided Versus Standard Ibuprofen Treatment for Patent Ductus Arteriosus NCT01593163 | Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz | Phase 3 |
| Terminated | Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure NCT00833365 | University of Utah | N/A |
| Completed | Efficacy and Safety of Oral Versus Intravenous Ibuprofen for PDA Treatment in ELBW Infants NCT01261117 | Zekai Tahir Burak Women's Health Research and Education Hospital | N/A |
| Completed | Timing for the Medical Treatment of Patent Ductus Arteriosus in Preterm Infants NCT00795990 | University of Utah | — |
| Completed | AMPLATZER Duct Occluder II Clinical Study NCT00713700 | Abbott Medical Devices | N/A |
| Terminated | An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infa NCT00750581 | University of Calgary | Phase 2 / Phase 3 |
| Completed | Feeding During Ibuprofen or Indomethacin Treatment of Preterm Infants NCT00728117 | University of California, San Francisco | N/A |
| Unknown | Treating the Resistant Patent Ductus Arteriosus (PDA) NCT00616382 | Shaare Zedek Medical Center | Phase 2 |
| Withdrawn | Brain, Gut and Kidney Blood Flow During Medical Closure of PDA NCT00554307 | University of Louisville | — |
| Terminated | Timing of PDA Closure and Respiratory Outcome in Premature Infants NCT00802685 | University of Miami | N/A |
| Completed | Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants NCT01758913 | Taipei Medical University Hospital | N/A |
| Completed | Comparative Study of Efficacy and Safety of Oral Ibuprofen and Intravenous Ibuprofen in Closure of Patent Duct NCT00642330 | Hopital La Rabta | Phase 4 |
| Terminated | Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants NCT00767039 | Alan Fujii | Phase 4 |
| Completed | Ibuprofen and Renal Function in Premature Infants NCT00217191 | Maternite Regionale Universitaire | Phase 4 |
| Completed | The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Prematur NCT00500305 | University of Virginia | N/A |
| Completed | Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With NCT00187447 | University of California, San Francisco | Phase 2 |
| Completed | Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA NCT00440804 | Farmacon | Phase 3 |
| Completed | Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA NCT00485160 | Shaare Zedek Medical Center | Phase 3 |
| Completed | Nitric Oxide, Endothelin-1, and the Patency of Ductus Arteriosus in Preterm Infants NCT00162903 | National Taiwan University Hospital | — |
| Completed | Long Term Results of 450 Percutaneous Closures of PDA in a Single Center NCT01929733 | Rambam Health Care Campus | — |