| Recruiting | Laser Acupuncture for Otitis Media With Effusion in Children NCT07242001 | Indonesia University | N/A |
| Unknown | Microplastics in Otitis Media With Effusion Material NCT06316635 | Kerem Kökoğlu | — |
| Recruiting | Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Re NCT05915078 | Smith & Nephew, Inc. | — |
| Unknown | The Effects of Exosomes in Otitis Media With Effusion NCT05402267 | Eye & ENT Hospital of Fudan University | — |
| Recruiting | Sound Ear Check (SEC) in Hearing Diagnostics in Young Children NCT05535634 | Vesa Lahdes | — |
| Recruiting | Coherent Optical Detection of Middle Ear Disease NCT05353569 | Medical College of Wisconsin | N/A |
| Unknown | Autoinflation: Alternative in the Treatment of Otitis Media With Effusion NCT05324696 | Instituto de Ciências Biomédicas Abel Salazar | N/A |
| Unknown | Secretory Otitis Media in Adenoids Hypertrophy Patients NCT04584073 | Assiut University | N/A |
| Unknown | A Non-invasive Device to Remove Fluid From the Middle Ear NCT03978195 | Yuinvent Innovations Ltd. | N/A |
| Completed | Study of the Expression of MMPs in OME in Children With Atrophy of the Eardrum NCT03611842 | University Hospital, Montpellier | — |
| Completed | Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion NCT03590912 | Lumbini Medical College | Phase 4 |
| Unknown | The Efficacy of Nasal Steroids in Treatment of Otitis Media With Effusion: Acomparative Study NCT03491098 | Muteea Mubark Salmen Bakuwiri | EARLY_Phase 1 |
| Completed | Tympanostomy Tube Extrusion Time & Viscosity NCT03848026 | Bezmialem Vakif University | — |
| Withdrawn | Xylitol for Otitis Media NCT02950311 | Duke University | Phase 2 / Phase 3 |
| Completed | The URT and Middle Ear Microbiota in Health and During Chronic OME NCT03109496 | University Hospital, Antwerp | — |
| Completed | Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion NCT03277820 | University Hospital, Antwerp | N/A |
| Completed | Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy NCT02716376 | Zealand University Hospital | N/A |
| Completed | Wideband Tympanometry in Otitis Media With Effusion NCT04395261 | Pamukkale University | — |
| Completed | Novel Imaging of the Eustachian Tube; Patient Study NCT02282540 | Oslo University Hospital | N/A |
| Completed | Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media NCT02858388 | Galsor S.r.l. | Phase 3 |
| Completed | Wide Frequency Band Test of Hearing in Veterans NCT02019888 | VA Office of Research and Development | — |
| Unknown | Acupuncture Effect on Inflammatory Markers in Pediatric Otitis Media With Effusion: A Pilot Study NCT02215681 | Ziv Hospital | N/A |
| Completed | OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement NCT01949155 | Otonomy, Inc. | Phase 3 |
| Completed | OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement NCT01949142 | Otonomy, Inc. | Phase 3 |
| Completed | A Novel Objective Diagnostic Test for Otitis Media With Effusion NCT02179541 | Nazan Degirmenci | — |
| Completed | Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion NCT02183974 | University Hospital Ostrava | N/A |
| Completed | Three Methods Used in the Diagnosis of EER in Children With OME NCT02183961 | University Hospital Ostrava | N/A |
| Unknown | Device Study to Evaluate the Detection and Characterization of Middle Ear Fluid in Children NCT01421199 | OtoSonics Inc. | N/A |
| Completed | Evaluation of the Tympanostomy Tube Delivery System NCT01202578 | Integra LifeSciences Corporation | Phase 2 / Phase 3 |
| Completed | Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children NCT01082029 | Hamilton Health Sciences Corporation | Phase 4 |
| Completed | Clinical Study of the Tympanostomy Tube Delivery System NCT00939796 | Integra LifeSciences Corporation | N/A |
| Completed | Otitis Media With Effusion and Type 2 Inflammation Diseases NCT06403319 | Hearing and Language Healthcare Center, China Medical University Hsinchu Hospital, Taiwan | — |
| Withdrawn | Food Allergy - Tubes - Adenoids (FATA) Trial NCT00736112 | University of Missouri-Columbia | N/A |
| Completed | A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion NCT00546117 | Washington University School of Medicine | N/A |
| Completed | Osteopathic Otitis Media Research Study NCT00520039 | West Virginia School of Osteopathic Medicine | N/A |
| Completed | Adenoidectomy, Myringotomy and Tubes' Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis NCT00629694 | Aghia Sophia Children's Hospital of Athens | Phase 2 |
| Completed | Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion NCT00393900 | University of Pittsburgh | — |
| Completed | Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media NCT00195611 | Wyeth is now a wholly owned subsidiary of Pfizer | — |
| Completed | Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays NCT00279916 | Mayo Clinic | Phase 3 |
| Terminated | Adenoidectomy for Otitis Media in 2-3 Year Old Children NCT00016497 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Phase 3 |
| Withdrawn | The Effect of Osteopatic Cranial Techniques on the Audiometric and Tympanometric Values in Children Suffering NCT00547326 | University Hospital, Ghent | N/A |