| Not Yet Recruiting | Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions NCT06876038 | University of Massachusetts, Boston | Phase 2 |
| Recruiting | Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive S NCT07343596 | University of Wisconsin, Madison | N/A |
| Recruiting | Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatme NCT07209189 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 |
| Recruiting | A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Canc NCT07063212 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Not Yet Recruiting | Dysphagia and Quality of Life in Patients With Oral Squamous Cell Carcinoma Before and After Treatment NCT06407570 | University of Aarhus | — |
| Withdrawn | A Study of Concurrent Chemoradiation in Combination With or Without PD1 Inhibitor AB122 Adenosine 2a Receptor NCT04892875 | Jennifer Choe | Phase 1 |
| Recruiting | Evaluation of the Benefit of a New Surgical Procedure According to IDEAL Recommendations for ORL Cancer Patien NCT05757817 | Institut Claudius Regaud | N/A |
| Recruiting | Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy NCT05793151 | Medical University of South Carolina | N/A |
| Unknown | WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA NCT05927220 | Armed Forces Institute of Pathology Rawalpindi | — |
| Active Not Recruiting | The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors NCT05798780 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Recruiting | Radial Forearm Donor Site Closure NCT05740033 | University of British Columbia | N/A |
| Completed | Risk Factors Contributing to Oral Cancer in Patients at Dr. Hasan Sadikin General Hospital Bandung NCT06690918 | Universitas Padjadjaran | — |
| Active Not Recruiting | Predictive Tools in Head and Neck Cancer Patients Undergoing Radiotherapy NCT06806683 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Mandibular Reconstruction Preplanning (ViPMR) NCT05429099 | University of British Columbia | Phase 2 / Phase 3 |
| Recruiting | Immune Biomarker Study for Head and Neck Cancer NCT05375266 | University of Erlangen-Nürnberg Medical School | — |
| Completed | Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis NCT05369234 | Covenant Health Cancer Center | Phase 3 |
| Recruiting | Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers NCT04809324 | Dr.Pankaj Chaturvedi | N/A |
| Recruiting | Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy NCT05337631 | University Hospital Freiburg | — |
| Completed | Efficacy of Swallowing Function After Early Postoperative Oral Exercise Among Patient With Oral Cavity Cancer NCT05056064 | Department of Medical Services Ministry of Public Health of Thailand | N/A |
| Active Not Recruiting | Candonilimab and ATRA Acid for Prevention of Oral Cancer Recurrence in Patients With OPL NCT06728631 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Completed | Radiotherapy of Head and Neck Cancer Using an Intraoral Stent NCT04330781 | Oslo University Hospital | Phase 2 |
| Unknown | Sintilimab to Prevent High-risk Oral Premalignant Lesions Cancerization NCT04065737 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Terminated | CytID Analysis of Oral Lesions NCT03555721 | The University of Texas Health Science Center, Houston | — |
| Completed | Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy NCT03267914 | A.T. Still University of Health Sciences | N/A |
| Completed | Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinom NCT03082534 | University of California, San Diego | Phase 2 |
| Completed | Adaptive Radiotherapy for Head and Neck Cancer NCT03096808 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Unknown | Cell-free Tumor DNA in Head and Neck Cancer Patients NCT03942380 | Christian von Buchwald | N/A |
| Completed | CaptHPV : Validation of the Method "CaptHPV" for the Diagnosis of Human Papillomavirus Associated Infiltrating NCT02981862 | Institut de Cancérologie de Lorraine | N/A |
| Completed | Pembrolizumab in Combination With CRT for LA-SCCHN NCT02586207 | Sanford Health | Phase 1 |
| Completed | Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients NCT02412241 | Vanderbilt-Ingram Cancer Center | N/A |
| Recruiting | Integrated Cancer Repository for Cancer Research NCT02012699 | University of Nebraska | — |
| Recruiting | Screening for Cancers in the Oral CAvity NCT01958762 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma NCT01695122 | Instituto do Cancer do Estado de São Paulo | Phase 2 |
| Completed | Study to Assess Biomarkers in Patients With Resectable Oral Cavity Cancer Randomized to Receive Preoperative T NCT01116843 | University Health Network, Toronto | Phase 1 / Phase 2 |
| Completed | Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer NCT01084733 | Mahesh Kudrimoti | — |
| Terminated | A Study of High-Risk Oral Cavity Cancer NCT00934739 | National Health Research Institutes, Taiwan | Phase 2 / Phase 3 |
| Completed | Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in NCT00359645 | Gustave Roussy, Cancer Campus, Grand Paris | Phase 3 |
| Completed | Smoking Status and Body Image in Oral Cancer Patients NCT00412490 | M.D. Anderson Cancer Center | — |