| Not Yet Recruiting | Naloxone for Opioid Associated Out of Hospital Cardiac Arrest NCT06251609 | University of California, San Francisco | Phase 2 |
| Not Yet Recruiting | A Bundled Intervention to End Opioid Overdoses NCT07485335 | University of Alabama at Birmingham | Phase 4 |
| Not Yet Recruiting | Serious Game to Teach Opioid Overdose Response NCT06727786 | University of Nevada, Reno | Phase 2 |
| Not Yet Recruiting | Evaluation of Clinical Decision Support in Opioid Tapering NCT06527079 | University of Colorado, Denver | — |
| Recruiting | A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overd NCT07079241 | Region Skane | N/A |
| Not Yet Recruiting | UnityPhilly Response App for Overdose Reversal NCT06466005 | Drexel University | — |
| Completed | Quantitative Xylazine Measurement in ED NCT06949605 | Icahn School of Medicine at Mount Sinai | — |
| Recruiting | Machine-Learning Prediction and Reducing Overdoses With EHR Nudges NCT06806163 | University of Pittsburgh | N/A |
| Recruiting | A Bundled Intervention NCT06593093 | University of Alabama at Birmingham | Phase 1 / Phase 2 |
| Withdrawn | Nalmefene vs Naloxone for the Treatment of Recurrent Respiratory Depression After Opioid Overdose NCT06408714 | University of New Mexico | Phase 3 |
| Withdrawn | Blood Naloxone Levels Following Intradermal Injection in Humans NCT05876572 | Johns Hopkins University | Phase 4 |
| Enrolling By Invitation | Clinical Decision Support to Improve System Naloxone Co-prescribing NCT06271668 | University of Colorado, Denver | — |
| Recruiting | Vending Machine Naloxone Distribution for Your Community (VENDY) NCT06429436 | University of Colorado, Denver | Phase 4 |
| Completed | Opioid Rapid Response System: Naloxone Training in Communities NCT06238128 | University of Missouri-Columbia | N/A |
| Recruiting | Improving Availability of Intranasal Naloxone NCT05877118 | Hartford Hospital | N/A |
| Completed | Safety, Tolerability, and Pharmacokinetics of CSX-1004 NCT06005402 | Cessation Therapeutics, Inc. | Phase 1 |
| Withdrawn | Clinical Outcomes From Nalmefene NCT05808881 | Purdue Pharma LP | Phase 4 |
| Withdrawn | Tailoring Overdose Education for Black Churches NCT05645016 | New York State Psychiatric Institute | N/A |
| Active Not Recruiting | Health Insurance Instability and Mortality Among Patients Receiving Bup Tx for OUD NCT05944133 | Kaiser Permanente | — |
| Unknown | Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose NCT04815590 | BC Centre on Substance Use | — |
| Completed | Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg NCT06719986 | Purdue Pharma LP | Phase 1 |
| Completed | Pharmacokinetics (PK) and Safety of Multiple Doses of Intranasal Naloxone in Healthy Adults NCT05377255 | Emergent BioSolutions | Phase 1 |
| Completed | Peer Intervention to Link Overdose Survivors to Treatment (PILOT) NCT05123027 | Medical University of South Carolina | N/A |
| Withdrawn | Surviving Opioid Overdose With Naloxone Education and Resuscitation Trial (SOONER) NCT04740099 | Unity Health Toronto | N/A |
| Completed | Preventing Overdose Using Information and Data From the Environment NCT05096429 | Brown University | N/A |
| Terminated | Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal NCT05114460 | New York State Psychiatric Institute | Phase 2 |
| Completed | Pharmacokinetic Evaluation of Intranasal Nalmefene Using Three Dosing Regimens NCT05219669 | Opiant Pharmaceuticals Inc | Phase 1 |
| Completed | Ultrasound-guided PENG Block in Total Hip Replacement NCT04984109 | Tanta University | N/A |
| Unknown | European Cohort Study of the Effectiveness of Take Home Naloxone NCT05072249 | King's College London | — |
| Recruiting | Young Houston Emergency Opioid Engagement System NCT04811014 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | A Single-Dose, Bioequivalence Study of FMXIN001 4 mg Microspheres Powder NCT04713709 | Nasus Pharma | Phase 1 |
| Unknown | Opioids and Police Safety Study NCT05008523 | New York University | N/A |
| Completed | Pharmacokinetic Evaluation of a New Naloxone Nasal Swab, Naloxone Nasal Spray, and Intramuscular Naloxone Inje NCT05363501 | Pocket Naloxone Corp | Phase 1 |
| Completed | Developing and Testing the Opioid Rapid Response System NCT04589676 | Real Prevention, LLC | N/A |
| Completed | Multi-Center Randomized Controlled Trial of Relay- NYC's Nonfatal Overdose Response Program NCT04317053 | NYU Langone Health | N/A |
| Completed | The Rhode Island Prescription and Illicit Drug Study NCT04372238 | Brown University | N/A |
| Completed | User Acceptability of a Device-Based Opioid Overdose Intervention NCT04530591 | University of Pennsylvania | — |
| Completed | Development of a Tracheal Sound Sensor NCT05506267 | Thomas Jefferson University | — |
| Completed | Preventing Opioid Overdose Mortality in the United States NCT03924505 | RTI International | N/A |
| Unknown | Measures to Improve Outcomes After an Opioid Overdose NCT03968237 | Nassima Ait-Daoud Tiouririne | — |
| Completed | Incidence and Predictors of Opioid Overdose and Death Among Long-Term Users of Opioid Analgesics NCT02662153 | Member Companies of the Opioid PMR Consortium | — |
| Completed | Preventing Opioid Overdose Deaths by Empowering Pharmacists to Dispense Naloxone NCT05093309 | Auburn University | N/A |
| Completed | Risks and Benefits of Naloxone Prescribing NCT02535494 | New York State Psychiatric Institute | N/A |
| Completed | Project OOPEN: Opioid Overdose Prevention, Education and Intervention NCT01788306 | University of Washington | Phase 4 |
| Unknown | Naloxone Nasal Spray Pharmacokinetic Study NCT01622504 | Mitovie Pharma Ltd | Phase 1 |