| Not Yet Recruiting | A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis NCT06900192 | Stanford University | Phase 1 |
| Recruiting | Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS NCT06390930 | Shirley Ryan AbilityLab | N/A |
| Recruiting | Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis (Switzerland) NCT06526364 | University Hospital, Basel, Switzerland | — |
| Completed | PET Study of PIPE-791 in Healthy Volunteers and Volunteers With PrMS and IPF NCT06683612 | Contineum Therapeutics | Phase 1 |
| Active Not Recruiting | The Synergistic Effects of AIH and FES in Persons With MS NCT06413602 | Shirley Ryan AbilityLab | N/A |
| Active Not Recruiting | KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive NCT06384976 | Kyverna Therapeutics | Phase 2 |
| Recruiting | Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis NCT06516458 | Shirley Ryan AbilityLab | — |
| Recruiting | Intermittent Hypoxia in Persons With Multiple Sclerosis NCT06276634 | Shirley Ryan AbilityLab | N/A |
| Recruiting | A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Prog NCT06138132 | Stanford University | Phase 1 |
| Completed | The Effects of In-phase Bilateral Exercise in People with Progressive Multiple Sclerosis NCT06436131 | Cyprus University of Technology | N/A |
| Completed | An Observational Biomarker Study in Multiple Sclerosis (MS) Patients NCT05663853 | LAPIX Therapeutics Inc. | — |
| Recruiting | Cladribine vs Placebo for Non-active Progressive Multiple Sclerosis (CLASP-MS). NCT05961644 | Institute of Psychiatry and Neurology, Warsaw | Phase 2 / Phase 3 |
| Unknown | MUSCLE - Nordic Walking in MUltiple SCLErosis NCT05385731 | Leonardo A. Peyré-Tartaruga | N/A |
| Unknown | Exercise Effects in Multiple Sclerosis NCT05496881 | University of Regina | N/A |
| Completed | Novel Imaging Markers in SPMS NCT05357833 | University of Utah | EARLY_Phase 1 |
| Active Not Recruiting | Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis NCT05168384 | Abu Dhabi Stem Cells Center | Phase 1 / Phase 2 |
| Active Not Recruiting | Neuroprotection With N-acetyl Cysteine for Patients With Progressive Multiple Sclerosis NCT05122559 | Emmanuelle Waubant, MD PhD | Phase 2 |
| Recruiting | MS-ResearchBiomarkerS NCT05204459 | Cedars-Sinai Medical Center | — |
| Completed | Motor Asymmetry in Progressive Multiple Sclerosis Patients NCT04918225 | Rennes University Hospital | — |
| Unknown | Hydroxychloroquine and Indapamide in SPMS NCT05013463 | University of Calgary | Phase 2 |
| Unknown | Discontinuing Disease-modifying Therapies in Stable Relapsing - Onset Multiple Sclerosis (DOT-MS). NCT04260711 | Amsterdam UMC, location VUmc | N/A |
| Completed | Phase II Clinical Trial of OCH-NCNP1 NCT04211740 | National Center of Neurology and Psychiatry, Japan | Phase 2 |
| Unknown | Sensitivity of Motor Assessment in MS - a Prospective Cohort Study NCT04993274 | Friedemann Paul | — |
| Completed | Cortical Lesions in Patients With Multiple Sclerosis NCT03653585 | Danish Research Centre for Magnetic Resonance | — |
| Completed | Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis NCT02988401 | Johns Hopkins University | Phase 1 / Phase 2 |
| Completed | Open-label Study of Liothyronine in MS NCT02506751 | Johns Hopkins University | Phase 1 |
| Terminated | BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis NCT02430532 | Biogen | Phase 3 |
| Completed | Domperidone in Secondary Progressive Multiple Sclerosis (SPMS) NCT02308137 | University of Calgary | Phase 2 |
| Unknown | Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS NCT02273635 | Innobioscience SpA | Phase 1 / Phase 2 |
| Completed | Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis NCT01982942 | MediciNova | Phase 2 |
| Completed | Imaging of Intracerebral Inflammation in MS NCT02305264 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis NCT01433497 | AB Science | Phase 3 |
| Completed | Bayer/Cognitive Assessments With Multiple Sclerosis Subjects NCT00888277 | University of Louisville | — |
| Terminated | Efficacy and Safety of MBP8298 in Subjects With Secondary Progressive Multiple Sclerosis NCT00468611 | BioMS Technology Corp. | Phase 3 |
| Completed | Dose-Escalation Study of T Cell Vaccine in Multiple Sclerosis NCT00587691 | Opexa Therapeutics, Inc. | Phase 1 / Phase 2 |