NCT05496881

Exercise Effects in Multiple Sclerosis

Evaluating Task-Oriented Exercise Effects on Walking Function and the Central Nervous System in People With Multiple Sclerosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (estimated)
• Sponsor: University of Regina · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A growing body of work suggests that regular exercise can support symptom management and improve physical function for people living with multiple sclerosis (MS). Although exercise is known to be beneficial for managing many symptoms related to MS, its effects on the central nervous system, and whether these effects change with different types of exercise, are not well understood. Here, the investigators have designed a clinical trial that compares the effects of distinct exercise protocols on aspects of physical function, physical fitness, and central nervous system function. This research will be the first to compare the effects of different types of exercise on central nervous system changes in people with MS.

Detailed description

A total of 69 participants with multiple sclerosis (MS) and moderate motor disability in the province of Saskatchewan, Canada will be randomly assigned to receive one of three distinct exercise programs. All exercise programs will be delivered three times per week in 60-minute group sessions over the course of 12 weeks under the supervision of Clinical Exercise Physiologists. Exercise programming will include activities focused on mobility, fitness, and flexibility. Assessments of physical function, physical fitness, and central nervous system function will be conducted immediately before, after, and six weeks following completion of the exercise programs.

Conditions

• Multiple Sclerosis, Primary Progressive
• Multiple Sclerosis, Relapsing-Remitting
• Multiple Sclerosis, Secondary Progressive
• Multiple Sclerosis, Chronic Progressive
• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	Exercise Group 1	Prescribed exercises will focus on mobility and balance.
OTHER	Exercise Group 2	Prescribed exercises will focus on physical fitness.
OTHER	Exercise Group 3	Prescribed exercises will focus on flexibility, range of motion, and muscle tone.

Timeline

• Start date: 2022-06-15
• Primary completion: 2024-10-31
• Completion: 2025-04-30
• First posted: 2022-08-11
• Last updated: 2024-02-15

Locations

1 site across 1 country: Canada