| Not Yet Recruiting | Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment NCT07512193 | Johns Hopkins University | N/A |
| Not Yet Recruiting | Cognitive-Motor Training for AD/ADRD Prevention NCT07160582 | University of Illinois at Chicago | N/A |
| Not Yet Recruiting | Telehealth-Adapted Compensatory Training and Intervention for Cognition NCT07366346 | University of Florida | N/A |
| Not Yet Recruiting | Ketogenic Diet to Reduce Osteoarthritis Pain in MCI NCT07417891 | University of Kansas Medical Center | N/A |
| Not Yet Recruiting | Validation of the Montreal Cognitive Assessment (MoCA) Version 8.x and MoCA-MIS in Greece. NCT07297121 | Aristotle University Of Thessaloniki | — |
| Not Yet Recruiting | FACE Phase II (a Stage II Trial) NCT07130669 | Stanford University | Phase 1 / Phase 2 |
| Recruiting | Multi-modal Large Language Model-Empowered Talk Therapy for Older Adults With ADRD NCT07499570 | Indiana University | N/A |
| Recruiting | Exploring the Utility of [18F]3F4AP for Demyelination Imaging NCT06999434 | Yale University | Phase 1 |
| Enrolling By Invitation | Validation Study of a New Digital Diagnostic and Treatment Test Based on Interactive Video Games for Alzheimer NCT06963879 | Braingaze | N/A |
| Recruiting | Acute Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity NCT06962501 | University Department of Geriatric Medicine FELIX PLATTER | N/A |
| Recruiting | Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases NCT07235111 | Ospedale Policlinico San Martino | — |
| Recruiting | The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients NCT07244770 | Beni-Suef University | — |
| Recruiting | Efficacy and Safety of Dimethyl Fumarate Among Patients with Mild Cognitive Impairment and Dementia Due to Alz NCT06850597 | Medical University of Lodz | Phase 2 |
| Enrolling By Invitation | ViewMind Atlas Cognition NCT06746844 | ViewMind | N/A |
| Active Not Recruiting | Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation NCT06633952 | University of California, San Francisco | N/A |
| Recruiting | Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults NCT06633978 | University of California, San Francisco | N/A |
| Recruiting | Amyloid PET in Patients With Mild Cognitive Impairment and Early Dementia NCT06402370 | University Hospital, Ghent | — |
| Recruiting | Enhancing Attention and Wellbeing Using Digital Therapeutics NCT06397469 | University of California, San Francisco | N/A |
| Recruiting | Neuromodulation of Memory in Aging NCT05460468 | Duke University | N/A |
| Recruiting | The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function NCT06335836 | The First Affiliated Hospital with Nanjing Medical University | — |
| Completed | Cognitive Therapy Software for Improving Cognitive Function for Patients With Mild Cognitive Impairment NCT06264557 | Rowan | N/A |
| Completed | Detecting an MCI and Amyloid Digital Neuro Signature(DNS) Using Altoida's Multimodal Digital Biomarkers. NCT06223438 | Altoida | — |
| Completed | Impact of Nutrition, Sleep, and Physical Activity on Intellectual Function and Muscle Mass in Older Adults NCT06135740 | Tokyo University | N/A |
| Completed | A Phase I Clinical Study on the Safety and Pharmacokinetics of [18F]Florbetazine Injection NCT06593626 | HTA Co., Ltd. | Phase 1 |
| Not Yet Recruiting | iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS NCT05810454 | iPACES LLC | N/A |
| Completed | Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI) NCT05563298 | Unity Health Toronto | EARLY_Phase 1 |
| Completed | Promoting In-Home Activities at a Memory & Aging Clinic NCT05771064 | University of Illinois at Chicago | Phase 1 |
| Unknown | Effects and Mechanism of the Fully Immersive Virtual Reality Cognitive Training Based on Leisure Activities NCT05682469 | Chang Gung Memorial Hospital | N/A |
| Active Not Recruiting | A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011) NCT05637801 | Cognito Therapeutics, Inc. | N/A |
| Completed | Senior Driving Simulation Training for Subjective Cognitive Decline and Mild Cognitive Impairment NCT05380284 | Taipei Medical University | N/A |
| Recruiting | Identification of Neuroinflammation and Neuroimaging Biomarkers Through Data Driven Artificial Intelligence Te NCT06746909 | IRCCS Fondazione Stella Maris | N/A |
| Recruiting | Neurocognitive Assessment Platform 4 Alzheimer NCT07272811 | IRCCS San Raffaele | — |
| Unknown | Effects of the Fully Immersive VR Cognitive Training Based on Leisure Activities for the Elderly With MCI and NCT04779671 | Chang Gung Memorial Hospital | N/A |
| Unknown | The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI) NCT05009524 | iPACES LLC | N/A |
| Unknown | Validation Study of a New Digital Treatment Test NCT04897464 | Braingaze | N/A |
| Completed | BRain Energy Activation With Ketones to Prevent Alzheimer's Disease NCT04466735 | Université de Sherbrooke | N/A |
| Completed | Motor-cognitive Interventions Are Effective in Improving Cognitive Function in Older Adults With Mild Cognitiv NCT05764421 | Jinxuan Cheng | N/A |
| Recruiting | Cognitive Impairment in Ageing People NCT04360200 | Yamei Tang | — |
| Completed | PJ-011726 IntelliSpace Cognition MCI Study NCT04243642 | Philips Electronics Nederland B.V. acting through Philips CTO organization | — |
| Completed | Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbar NCT04095377 | QuantalX Neuroscience | — |
| Completed | Characterization of the DELPhI System in Assessing Brain's Functionality in Different Neurological Disorders NCT03832413 | QuantalX Neuroscience | — |
| Completed | Bilateral Brain Dynamics in Cognition and Aging NCT03224988 | Duke University | — |
| Active Not Recruiting | Tau PET Imaging in the NACC Study Cohort NCT03189485 | University of Pennsylvania | — |
| Unknown | The Interactive Physical and Cognitive Exercise System NCT03069391 | Union College, New York | N/A |
| Unknown | Detecting Dementia Earlier NCT03900936 | South Tees Hospitals NHS Foundation Trust | — |
| Completed | Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease NCT02380573 | The University of Texas Health Science Center at San Antonio | Phase 2 |
| Completed | Usability of Virtual Reality in Subjects With Mild Cognitive Impairment or Alzheimer's Disease NCT02176629 | Centre Hospitalier Universitaire de Nice | N/A |
| Completed | tDCS Intervention in Primary Progressive Aphasia NCT02606422 | Johns Hopkins University | N/A |
| Unknown | Early Detection of Cognitive Dysfunction in Diabetes NCT01830998 | Wuhan General Hospital of Guangzhou Military Command | — |