NCT04466735

BRain Energy Activation With Ketones to Prevent Alzheimer's Disease

6 Month Randomized Controlled Trial With D-beta-hydroxybutyrate in Mild Cognitive Impairment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Université de Sherbrooke · Academic / Other
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: Accepted

Summary

A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS). Outcomes: brain energy metabolism, cognition, plasma biomarkers, brain imaging (volumetric, functional, structural) and quality of life will be analyzed before and after the intervention.

Conditions

• MCI

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Active group	2 x 12 g of EKS/day
DIETARY_SUPPLEMENT	Placebo group	Isocaloric placebo supplement with similar salt load but no EKS

Timeline

• Start date: 2020-10-15
• Primary completion: 2024-12-12
• Completion: 2025-03-10
• First posted: 2020-07-10
• Last updated: 2025-06-03

Locations

1 site across 1 country: Canada