| Recruiting | Efficacy of Laser Interstitial Thermal Therapy in Young Persons With Low-grade Glioma NCT07506239 | University of California, San Francisco | N/A |
| Not Yet Recruiting | A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours NCT07441707 | Ipsen | Phase 1 |
| Recruiting | Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG NCT05555550 | Children's Hospital of Philadelphia | EARLY_Phase 1 |
| Recruiting | Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas NCT07110246 | University of California, San Francisco | Phase 2 |
| Recruiting | HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer) NCT06930846 | Dartmouth-Hitchcock Medical Center | N/A |
| Not Yet Recruiting | FCN-159 Monotherapy Versus Chemotherapy by Investigator's Choice in Pediatric Low-grade Glioma Patients With B NCT07004075 | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | Phase 3 |
| Recruiting | MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas NCT06712875 | Ann & Robert H Lurie Children's Hospital of Chicago | Phase 1 / Phase 2 |
| Recruiting | Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial NCT06132685 | Emory University | Phase 2 |
| Recruiting | FG001 in Subjects with Meningiomas or Presumed Low-Grade Gliomas Scheduled for Neurosurgery NCT06684795 | Rigshospitalet, Denmark | Phase 2 |
| Recruiting | Monitoring of Patients With Low-grade Gliomas Using Circulating miRNA NCT06610851 | University Hospital, Caen | — |
| Recruiting | Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Gr NCT06381570 | Daniel Morgenstern | EARLY_Phase 1 |
| Recruiting | Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Lo NCT05964569 | University Hospital Heidelberg | Phase 2 |
| Recruiting | A Study of Avutometinib for People With Solid Tumor Cancers NCT06104488 | Memorial Sloan Kettering Cancer Center | Phase 1 |
| Active Not Recruiting | Niraparib In Recurrent IDH 1/2 Gliomas NCT05406700 | Massachusetts General Hospital | EARLY_Phase 1 |
| Recruiting | Binimetinib in Patients With BRAF Fusion-positive Low-grade Glioma or Pancreatic Cancer (Perfume) NCT06159478 | National Cancer Center, Japan | Phase 2 |
| Recruiting | DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line NCT05566795 | Day One Biopharmaceuticals, Inc. | Phase 3 |
| Recruiting | A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With A NCT05538130 | Pfizer | Phase 1 |
| Recruiting | CEST in Low-grade Glioma Study NCT05996653 | Sunnybrook Health Sciences Centre | N/A |
| Withdrawn | GROW (Glioma Specialists Reaching Out With Support) Support NCT05233215 | Dana-Farber Cancer Institute | N/A |
| Completed | Evaluation of Cognitive and Motor Neurological Disorders in the Short and Long Term After Surgery for the Remo NCT05373394 | University Hospital, Tours | — |
| Recruiting | A Living Tissue Bank of Patient-Derived Organoids From Glioma Tumors NCT04865315 | Maastricht Radiation Oncology | — |
| Terminated | A Phase II Trial of Poly-ICLC for Low-Grade Gliomas NCT04544007 | University of Alabama at Birmingham | Phase 2 |
| Completed | SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue NCT04734444 | SonoClear AS | N/A |
| Recruiting | SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma NCT04923126 | St. Jude Children's Research Hospital | Phase 1 / Phase 2 |
| Recruiting | A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Gra NCT04775485 | Day One Biopharmaceuticals, Inc. | Phase 2 |
| Suspended | Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021) NCT04485559 | University of California, San Francisco | Phase 1 |
| Unknown | Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition NCT04174820 | University Hospital, Angers | — |
| Completed | Study of Recombinant Human Endostatin Combined With CV Regimen in the Treatment of Pediatric Low-grade Gliomas NCT04659421 | Beijing Sanbo Brain Hospital | Phase 2 |
| Active Not Recruiting | Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma NCT04553757 | M.D. Anderson Cancer Center | — |
| Terminated | Trial in Low Grade Glioma Patients: Wait or Treat NCT03763422 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 3 |
| Recruiting | A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma NCT04166409 | National Cancer Institute (NCI) | Phase 3 |
| Active Not Recruiting | A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Gra NCT03871257 | National Cancer Institute (NCI) | Phase 3 |
| Suspended | Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR NCT03952598 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas NCT03948490 | University of California, San Francisco | N/A |
| Active Not Recruiting | BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas NCT03749187 | University of California, San Francisco | Phase 1 |
| Active Not Recruiting | Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype NCT03718767 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms NCT04044937 | Thomas Hope | Phase 2 |
| Active Not Recruiting | Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway. NCT03363217 | St. Justine's Hospital | Phase 2 |
| Completed | Assessing the Effectiveness of 2D Non-Navigated Intraoperative Ultrasound in Glioma Surgery NCT05873946 | Hospital del Rio Hortega | — |
| Recruiting | Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery NCT04316039 | West China Hospital | Phase 2 / Phase 3 |
| Completed | DAY101 In Gliomas and Other Tumors NCT03429803 | Karen D. Wright, MD | Phase 1 |
| Completed | Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or NCT03213665 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Hist NCT03233204 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | Mind-Body Intervention in Glioma Couples NCT03244995 | M.D. Anderson Cancer Center | N/A |
| Active Not Recruiting | Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG) NCT02840409 | The Hospital for Sick Children | Phase 2 |
| Completed | Longitudinal MRI Assessment in Patients With Diffuse Low-grade Gliomas NCT04346472 | University Hospital, Montpellier | — |
| Completed | ROCOCO - Low Grade Glioma - Planning Study NCT02607397 | Maastricht Radiation Oncology | — |
| Active Not Recruiting | A Study Comparing Two Carboplatin Containing Regimens for Children and Young Adults With Previously Untreated NCT02455245 | Alicia Lenzen | Phase 3 |
| Recruiting | A Vaccine Trial for Low Grade Gliomas NCT02358187 | James Felker | Phase 2 |
| Completed | Phase II Trial of Oral Vinorelbine in Children With Recurrent or Progressive Unresectable Low-Grade Glioma NCT02197637 | Centre Oscar Lambret | Phase 2 |
| Terminated | Everolimus With and Without Temozolomide in Adult Low Grade Glioma NCT02023905 | University of California, San Francisco | Phase 2 |
| Completed | Rotating Frame Relaxation and Diffusion Weighted Imaging of Human Gliomas NCT02186262 | Turku University Hospital | — |
| Completed | A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas NCT01837862 | Julie Krystal | Phase 1 / Phase 2 |
| Terminated | Ovarian Aging in Low Grade Glioma (LGG) Treated With Temozolomide NCT01452854 | University of California, San Francisco | — |
| Completed | Vinorelbine for Children With Progressive or Recurrent Low-grade Gliomas NCT01497860 | Eugene Hwang | Phase 2 |
| Active Not Recruiting | Proton Radiation Therapy for Gliomas NCT01358058 | Massachusetts General Hospital | N/A |
| Completed | Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation NCT01288235 | Massachusetts General Hospital | Phase 2 |
| Terminated | (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas NCT01281982 | National Cancer Institute (NCI) | — |
| Active Not Recruiting | Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma NCT01089101 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | Evaluation de O-(2-[18F]-Fluoroethyl)-L-Tyrosine, a New Tracer PET, in the Diagnosis of Low Grade Glioma NCT02286531 | University Hospital, Toulouse | N/A |
| Completed | Everolimus (RAD001) for Children With Chemotherapy-Refractory Progressive or Recurrent Low-Grade Gliomas NCT00782626 | Dana-Farber Cancer Institute | Phase 2 |
| Approved For Marketing | Expanded Access Program (EAP) for Tovorafenib (DAY101) in RAF-Altered, Relapsed or Refractory Low-Grade Glioma NCT05760586 | Day One Biopharmaceuticals, Inc. | — |